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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SGSH All Species: 14.85
Human Site: Y286 Identified Species: 36.3
UniProt: P51688 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51688 NP_000190.1 502 56695 Y286 P S G R T N L Y W P G T A E P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001110101 502 56546 Y286 P S G R A N L Y W P G T A E P
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P50428 506 53758 C293 M R M S N G G C S G L L R C G
Rat Rattus norvegicus Q32KJ6 524 58284 G303 I S A P K E G G S N G P F L C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510198 185 21881
Chicken Gallus gallus Q5ZK90 535 61383 M310 L L K K T I I M F T S D H G E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q08CJ7 523 59480 S323 H R Q F Y K M S M F E G S S H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650760 524 59888 Y289 P G G R T N L Y E H G I R S P
Honey Bee Apis mellifera XP_623278 490 56473 Y267 P N G R T N L Y E P G L A E P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796819 504 57529 Y284 T S G R T N L Y E C G S R E P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96 N.A. N.A. 24.7 22.8 N.A. 29.4 21.8 N.A. 21 N.A. 52 59.5 N.A. 60.3
Protein Similarity: 100 N.A. 97.4 N.A. N.A. 40.1 37 N.A. 32 38.6 N.A. 38.2 N.A. 64.8 73.9 N.A. 74.8
P-Site Identity: 100 N.A. 93.3 N.A. N.A. 0 13.3 N.A. 0 6.6 N.A. 0 N.A. 60 80 N.A. 66.6
P-Site Similarity: 100 N.A. 93.3 N.A. N.A. 0 13.3 N.A. 0 26.6 N.A. 13.3 N.A. 60 86.6 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 10 0 0 0 0 0 0 0 30 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 10 0 0 0 10 10 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % D
% Glu: 0 0 0 0 0 10 0 0 30 0 10 0 0 40 10 % E
% Phe: 0 0 0 10 0 0 0 0 10 10 0 0 10 0 0 % F
% Gly: 0 10 50 0 0 10 20 10 0 10 60 10 0 10 10 % G
% His: 10 0 0 0 0 0 0 0 0 10 0 0 10 0 10 % H
% Ile: 10 0 0 0 0 10 10 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 10 10 10 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 10 0 0 0 0 50 0 0 0 10 20 0 10 0 % L
% Met: 10 0 10 0 0 0 10 10 10 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 10 50 0 0 0 10 0 0 0 0 0 % N
% Pro: 40 0 0 10 0 0 0 0 0 30 0 10 0 0 50 % P
% Gln: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 20 0 50 0 0 0 0 0 0 0 0 30 0 0 % R
% Ser: 0 40 0 10 0 0 0 10 20 0 10 10 10 20 0 % S
% Thr: 10 0 0 0 50 0 0 0 0 10 0 20 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _