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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARSD All Species: 7.58
Human Site: S504 Identified Species: 18.52
UniProt: P51689 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51689 NP_001660.2 593 64860 S504 G R G V C P C S G E G V T H H
Chimpanzee Pan troglodytes XP_520911 562 63294 S471 G S G I C S W S G D V T Y H D
Rhesus Macaque Macaca mulatta XP_001116129 589 65549 F501 G R K V C P C F G E K V L H H
Dog Lupus familis XP_548838 639 70828 S549 G R G V C P C S G D G V T Q H
Cat Felis silvestris
Mouse Mus musculus P50427 624 66572 G497 T H V C L C A G P A H V T A H
Rat Rattus norvegicus P15589 577 62660 H489 S T H V C M C H G H H V T H H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514413 576 63289 F484 G R E I C P C F G A H V T H H
Chicken Gallus gallus Q5ZK90 535 61383 T451 S A D P D E L T N V A I K F P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q08CJ7 523 59480 S439 F N L S K D E S E L R N I A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P50473 567 62459 E467 Y F L C S D C E G D C V T E H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.7 61.3 74.1 N.A. 47.1 48 N.A. 70.3 20.9 N.A. 22.7 N.A. N.A. N.A. N.A. 27.9
Protein Similarity: 100 71.8 71.8 81.2 N.A. 57.3 59.3 N.A. 79.7 36.9 N.A. 38.2 N.A. N.A. N.A. N.A. 42.1
P-Site Identity: 100 40 73.3 86.6 N.A. 20 53.3 N.A. 66.6 0 N.A. 6.6 N.A. N.A. N.A. N.A. 33.3
P-Site Similarity: 100 53.3 73.3 93.3 N.A. 20 53.3 N.A. 73.3 13.3 N.A. 6.6 N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 10 0 0 20 10 0 0 20 0 % A
% Cys: 0 0 0 20 60 10 60 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 10 0 10 20 0 0 0 30 0 0 0 0 10 % D
% Glu: 0 0 10 0 0 10 10 10 10 20 0 0 0 10 0 % E
% Phe: 10 10 0 0 0 0 0 20 0 0 0 0 0 10 0 % F
% Gly: 50 0 30 0 0 0 0 10 70 0 20 0 0 0 0 % G
% His: 0 10 10 0 0 0 0 10 0 10 30 0 0 50 70 % H
% Ile: 0 0 0 20 0 0 0 0 0 0 0 10 10 0 0 % I
% Lys: 0 0 10 0 10 0 0 0 0 0 10 0 10 0 0 % K
% Leu: 0 0 20 0 10 0 10 0 0 10 0 0 10 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 0 0 0 0 10 0 0 10 0 0 0 % N
% Pro: 0 0 0 10 0 40 0 0 10 0 0 0 0 0 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Q
% Arg: 0 40 0 0 0 0 0 0 0 0 10 0 0 0 0 % R
% Ser: 20 10 0 10 10 10 0 40 0 0 0 0 0 0 10 % S
% Thr: 10 10 0 0 0 0 0 10 0 0 0 10 60 0 0 % T
% Val: 0 0 10 40 0 0 0 0 0 10 10 70 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _