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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARSD All Species: 8.48
Human Site: Y377 Identified Species: 20.74
UniProt: P51689 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51689 NP_001660.2 593 64860 Y377 L G G W N G I Y K G G K G M G
Chimpanzee Pan troglodytes XP_520911 562 63294 R358 G G W E G G I R V P G I F R C
Rhesus Macaque Macaca mulatta XP_001116129 589 65549 Y374 Y G G W N G I Y K G G K G M G
Dog Lupus familis XP_548838 639 70828 F422 L G G W N G I F R G G K G M G
Cat Felis silvestris
Mouse Mus musculus P50427 624 66572 V371 R M G G S N G V F R G G K G N
Rat Rattus norvegicus P15589 577 62660 I362 R H G G S N G I Y R G G K A N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514413 576 63289 Y357 L G G W N G R Y K G G K G M G
Chicken Gallus gallus Q5ZK90 535 61383 K348 V M G P G I R K Q Q Q V S A V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q08CJ7 523 59480 M336 S H V P L L I M G P G V K S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P50473 567 62459 P361 I P Y I V Y W P G T I S P G V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.7 61.3 74.1 N.A. 47.1 48 N.A. 70.3 20.9 N.A. 22.7 N.A. N.A. N.A. N.A. 27.9
Protein Similarity: 100 71.8 71.8 81.2 N.A. 57.3 59.3 N.A. 79.7 36.9 N.A. 38.2 N.A. N.A. N.A. N.A. 42.1
P-Site Identity: 100 26.6 93.3 86.6 N.A. 13.3 13.3 N.A. 93.3 6.6 N.A. 20 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 26.6 93.3 100 N.A. 20 20 N.A. 93.3 20 N.A. 20 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 10 0 0 0 10 0 0 % F
% Gly: 10 50 70 20 20 50 20 0 20 40 80 20 40 20 50 % G
% His: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 10 0 10 50 10 0 0 10 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 10 30 0 0 40 30 0 0 % K
% Leu: 30 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % L
% Met: 0 20 0 0 0 0 0 10 0 0 0 0 0 40 0 % M
% Asn: 0 0 0 0 40 20 0 0 0 0 0 0 0 0 20 % N
% Pro: 0 10 0 20 0 0 0 10 0 20 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 10 10 0 0 0 0 % Q
% Arg: 20 0 0 0 0 0 20 10 10 20 0 0 0 10 0 % R
% Ser: 10 0 0 0 20 0 0 0 0 0 0 10 10 10 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % T
% Val: 10 0 10 0 10 0 0 10 10 0 0 20 0 0 20 % V
% Trp: 0 0 10 40 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 10 0 0 10 0 30 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _