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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN2 All Species: 11.21
Human Site: S419 Identified Species: 24.67
UniProt: P51788 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51788 NP_004357.3 898 98535 S419 V E E L E P P S T S Q A W N P
Chimpanzee Pan troglodytes XP_527935 988 108838 S446 D P E S L G Q S A V W I H P R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545230 891 98238 G410 M E E L E P P G T S Q A W S P
Cat Felis silvestris
Mouse Mus musculus Q9R0A1 908 99419 S427 V E D L E L P S T S Q A W S P
Rat Rattus norvegicus P35525 907 99310 S425 V E D L G A P S T S Q A W S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 P404 T K Y R L L Y P A V V T F V I
Chicken Gallus gallus XP_425521 996 111070 S454 D P Q I L G K S A A W I H P K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001920936 1562 174909 S397 A E E F E Y S S H V P Q A W K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 V500 T V E Q A A V V T H W M T S Y
Honey Bee Apis mellifera XP_392015 919 102193 V395 G V E E M N I V K H W S T V Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001175776 603 66900 K149 G S G M P L G K E G P F V H I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49 N.A. 94.6 N.A. 93.2 93.5 N.A. 48.3 49.2 N.A. 43.1 N.A. 38.8 47 N.A. 40.9
Protein Similarity: 100 62.9 N.A. 96.2 N.A. 95.3 95.5 N.A. 62.9 64.6 N.A. 49.8 N.A. 53.1 62.7 N.A. 54
P-Site Identity: 100 13.3 N.A. 80 N.A. 80 73.3 N.A. 0 6.6 N.A. 26.6 N.A. 13.3 6.6 N.A. 0
P-Site Similarity: 100 13.3 N.A. 93.3 N.A. 93.3 86.6 N.A. 13.3 26.6 N.A. 26.6 N.A. 20 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 19 0 0 28 10 0 37 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 19 0 19 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 46 55 10 37 0 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 0 0 0 0 0 10 10 0 0 % F
% Gly: 19 0 10 0 10 19 10 10 0 10 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 10 19 0 0 19 10 0 % H
% Ile: 0 0 0 10 0 0 10 0 0 0 0 19 0 0 19 % I
% Lys: 0 10 0 0 0 0 10 10 10 0 0 0 0 0 19 % K
% Leu: 0 0 0 37 28 28 0 0 0 0 0 0 0 0 0 % L
% Met: 10 0 0 10 10 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 19 0 0 10 19 37 10 0 0 19 0 0 19 37 % P
% Gln: 0 0 10 10 0 0 10 0 0 0 37 10 0 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % R
% Ser: 0 10 0 10 0 0 10 55 0 37 0 10 0 37 0 % S
% Thr: 19 0 0 0 0 0 0 0 46 0 0 10 19 0 0 % T
% Val: 28 19 0 0 0 0 10 19 0 28 10 0 10 19 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 37 0 37 10 0 % W
% Tyr: 0 0 10 0 0 10 10 0 0 0 0 0 0 0 19 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _