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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN2 All Species: 13.03
Human Site: T691 Identified Species: 28.67
UniProt: P51788 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51788 NP_004357.3 898 98535 T691 F P A A R G E T H K P L K P A
Chimpanzee Pan troglodytes XP_527935 988 108838 D716 A F V D E D E D E D L S G K S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545230 891 98238 T682 F P A A R E E T H K P L K P A
Cat Felis silvestris
Mouse Mus musculus Q9R0A1 908 99419 T699 F S G A H G Q T H K P L K P A
Rat Rattus norvegicus P35525 907 99310 T697 F P G A H G Q T H K P L K P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 E663 M I L L G S V E R S E L Q T L
Chicken Gallus gallus XP_425521 996 111070 E724 D E D D D T D E K A E P Q P P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001920936 1562 174909 T669 S S Y S P T L T N S Q I P L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 L771 P A P D I L S L R Q I A N D E
Honey Bee Apis mellifera XP_392015 919 102193 M666 P A P D I L K M Q R Q S A N D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001175776 603 66900 I401 P V P S G V F I P V F T I G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49 N.A. 94.6 N.A. 93.2 93.5 N.A. 48.3 49.2 N.A. 43.1 N.A. 38.8 47 N.A. 40.9
Protein Similarity: 100 62.9 N.A. 96.2 N.A. 95.3 95.5 N.A. 62.9 64.6 N.A. 49.8 N.A. 53.1 62.7 N.A. 54
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 73.3 80 N.A. 6.6 6.6 N.A. 6.6 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 13.3 N.A. 93.3 N.A. 80 86.6 N.A. 13.3 20 N.A. 26.6 N.A. 6.6 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 19 37 0 0 0 0 0 10 0 10 10 0 46 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 10 37 10 10 10 10 0 10 0 0 0 10 10 % D
% Glu: 0 10 0 0 10 10 28 19 10 0 19 0 0 0 10 % E
% Phe: 37 10 0 0 0 0 10 0 0 0 10 0 0 0 0 % F
% Gly: 0 0 19 0 19 28 0 0 0 0 0 0 10 10 0 % G
% His: 0 0 0 0 19 0 0 0 37 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 19 0 0 10 0 0 10 10 10 0 0 % I
% Lys: 0 0 0 0 0 0 10 0 10 37 0 0 37 10 10 % K
% Leu: 0 0 10 10 0 19 10 10 0 0 10 46 0 10 10 % L
% Met: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 10 10 0 % N
% Pro: 28 28 28 0 10 0 0 0 10 0 37 10 10 46 10 % P
% Gln: 0 0 0 0 0 0 19 0 10 10 19 0 19 0 0 % Q
% Arg: 0 0 0 0 19 0 0 0 19 10 0 0 0 0 0 % R
% Ser: 10 19 0 19 0 10 10 0 0 19 0 19 0 0 10 % S
% Thr: 0 0 0 0 0 19 0 46 0 0 0 10 0 10 0 % T
% Val: 0 10 10 0 0 10 10 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _