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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN4 All Species: 12.12
Human Site: S143 Identified Species: 24.24
UniProt: P51793 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51793 NP_001821.2 760 84917 S143 S E L L V N Q S E G A S A Y I
Chimpanzee Pan troglodytes XP_001154165 791 87957 A174 A E L I I G Q A E G P G S Y I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848379 760 84902 S143 S E L L V N Q S E G A S A Y I
Cat Felis silvestris
Mouse Mus musculus Q61418 747 83956 M142 A Y I L N Y L M Y I L W A L L
Rat Rattus norvegicus P51794 747 83683 M142 A Y I L N Y L M Y I L W A L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515028 869 97095 S252 S E L L V N Q S E G A S A Y I
Chicken Gallus gallus XP_425575 680 76203 L101 I C M E S C S L D I L Y I K T
Frog Xenopus laevis Q9W701 689 76782 G110 A L V A F S T G F A Q S I T P
Zebra Danio Brachydanio rerio NP_001070786 768 85452 T152 A E L V T G Y T E G A G V Y V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 R205 N A R I W L Y R D L T S Q P F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92943 792 87043 P144 Y I I T Q F A P A A A G S G I
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 W148 E C E A Q G L W I A W K G H V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.2 N.A. 99.2 N.A. 96.3 97.3 N.A. 85 82.8 25.3 89 N.A. 20.2 N.A. N.A. N.A.
Protein Similarity: 100 85.5 N.A. 100 N.A. 97.5 98.1 N.A. 86.6 85.5 44.6 94.2 N.A. 34.4 N.A. N.A. N.A.
P-Site Identity: 100 46.6 N.A. 100 N.A. 13.3 13.3 N.A. 100 0 6.6 40 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 80 N.A. 100 N.A. 33.3 33.3 N.A. 100 13.3 26.6 66.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.6 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. 46.9 52.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 42 9 0 17 0 0 9 9 9 25 42 0 42 0 0 % A
% Cys: 0 17 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % D
% Glu: 9 42 9 9 0 0 0 0 42 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 9 9 0 0 9 0 0 0 0 0 9 % F
% Gly: 0 0 0 0 0 25 0 9 0 42 0 25 9 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 9 9 25 17 9 0 0 0 9 25 0 0 17 0 42 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 0 % K
% Leu: 0 9 42 42 0 9 25 9 0 9 25 0 0 17 17 % L
% Met: 0 0 9 0 0 0 0 17 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 17 25 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 9 0 0 9 0 0 9 9 % P
% Gln: 0 0 0 0 17 0 34 0 0 0 9 0 9 0 0 % Q
% Arg: 0 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % R
% Ser: 25 0 0 0 9 9 9 25 0 0 0 42 17 0 0 % S
% Thr: 0 0 0 9 9 0 9 9 0 0 9 0 0 9 9 % T
% Val: 0 0 9 9 25 0 0 0 0 0 0 0 9 0 17 % V
% Trp: 0 0 0 0 9 0 0 9 0 0 9 17 0 0 0 % W
% Tyr: 9 17 0 0 0 17 17 0 17 0 0 9 0 42 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _