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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN6 All Species: 19.7
Human Site: S243 Identified Species: 33.33
UniProt: P51797 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51797 NP_001277.1 869 97217 S243 R D K R D F V S A G A A A G V
Chimpanzee Pan troglodytes XP_514393 802 89426 S202 L F S L E E G S S F W N Q G L
Rhesus Macaque Macaca mulatta XP_001104721 869 97094 S243 R D K R D F V S A G A A A G V
Dog Lupus familis XP_535404 889 99260 S262 R D K R D F V S A G A A A G V
Cat Felis silvestris
Mouse Mus musculus O35454 870 96962 S243 R D K R D F V S A G A A A G V
Rat Rattus norvegicus P51799 803 88712 G203 E P V A A G S G I P Q I K C F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516296 878 97865 H250 G K E G P M I H S G A V V G A
Chicken Gallus gallus XP_417644 868 97172 S241 R D K R D F V S A G A A A G V
Frog Xenopus laevis Q9W701 689 76782 N89 L Q Q E L G G N V L L R Y L S
Zebra Danio Brachydanio rerio XP_696527 863 96883 G241 K R D F V S A G A A A G V A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396520 803 89642 V203 A G S G I P Q V K C Y L N G I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001193438 761 83935 K161 F Q S I T F R K F N F N F P Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92943 792 87043 E192 G G L A L G K E G P L V H T G
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 V179 S T L L V K Y V A P M A T G S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.2 99.4 93.3 N.A. 96.7 40.8 N.A. 81.3 93.2 22.7 82.6 N.A. N.A. 37.9 N.A. 49.8
Protein Similarity: 100 92.2 99.8 95.1 N.A. 98.7 58 N.A. 85.3 97.8 39.1 90.7 N.A. N.A. 57.3 N.A. 64.6
P-Site Identity: 100 13.3 100 100 N.A. 100 0 N.A. 20 100 0 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 33.3 100 100 N.A. 100 0 N.A. 40 100 13.3 20 N.A. N.A. 13.3 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 30 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 8 0 8 0 50 8 50 43 36 8 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % C
% Asp: 0 36 8 0 36 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 8 8 8 8 0 8 0 0 0 0 0 0 0 % E
% Phe: 8 8 0 8 0 43 0 0 8 8 8 0 8 0 8 % F
% Gly: 15 15 0 15 0 22 15 15 8 43 0 8 0 65 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 8 8 0 8 0 8 0 0 8 0 0 8 % I
% Lys: 8 8 36 0 0 8 8 8 8 0 0 0 8 0 0 % K
% Leu: 15 0 15 15 15 0 0 0 0 8 15 8 0 8 8 % L
% Met: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 8 0 15 8 0 0 % N
% Pro: 0 8 0 0 8 8 0 0 0 22 0 0 0 8 0 % P
% Gln: 0 15 8 0 0 0 8 0 0 0 8 0 8 0 0 % Q
% Arg: 36 8 0 36 0 0 8 0 0 0 0 8 0 0 0 % R
% Ser: 8 0 22 0 0 8 8 43 15 0 0 0 0 0 15 % S
% Thr: 0 8 0 0 8 0 0 0 0 0 0 0 8 8 0 % T
% Val: 0 0 8 0 15 0 36 15 8 0 0 15 15 0 36 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 8 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _