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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GUCY2F All Species: 20.91
Human Site: S540 Identified Species: 46
UniProt: P51841 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51841 NP_001513.2 1108 124822 S540 Q I T S E V Q S G R S P R L S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001098846 1108 125126 S540 Q I T S E V Q S G R F P R L S
Dog Lupus familis XP_538138 1108 124925 S540 R I T S E V Q S G R S P R L S
Cat Felis silvestris
Mouse Mus musculus Q5SDA5 1108 124407 S540 Q I I S E V Q S G R S P R L S
Rat Rattus norvegicus P51842 1108 124393 S540 Q I I S E V Q S G R S P R L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506097 1100 119406 K564 T R S V S D G K S L K S R E W
Chicken Gallus gallus XP_417281 1078 121075 R515 N S V A A E T R S Q K S T I H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103165 1107 124634 S543 K A S D T R M S I S E R S L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 N525 Y N N P T N K N I F Q I C R Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 S553 Q V R G K G A S R R S L Q S A
Sea Urchin Strong. purpuratus P16065 1125 126238 N568 S Q G F S M K N M V M S A I S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.5 91.4 N.A. 89.9 89.8 N.A. 51.3 60.7 N.A. 61.9 N.A. 31.5 N.A. 29.5 32.5
Protein Similarity: 100 N.A. 98.1 94.7 N.A. 93.7 93.5 N.A. 67.2 75 N.A. 75.9 N.A. 48.6 N.A. 47.9 50.4
P-Site Identity: 100 N.A. 93.3 93.3 N.A. 93.3 93.3 N.A. 6.6 0 N.A. 13.3 N.A. 0 N.A. 26.6 6.6
P-Site Similarity: 100 N.A. 93.3 100 N.A. 93.3 93.3 N.A. 13.3 20 N.A. 26.6 N.A. 13.3 N.A. 53.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 10 10 0 10 0 0 0 0 0 10 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 46 10 0 0 0 0 10 0 0 10 0 % E
% Phe: 0 0 0 10 0 0 0 0 0 10 10 0 0 0 0 % F
% Gly: 0 0 10 10 0 10 10 0 46 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 46 19 0 0 0 0 0 19 0 0 10 0 19 0 % I
% Lys: 10 0 0 0 10 0 19 10 0 0 19 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 10 0 10 0 55 0 % L
% Met: 0 0 0 0 0 10 10 0 10 0 10 0 0 0 0 % M
% Asn: 10 10 10 0 0 10 0 19 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 10 0 0 0 0 0 0 0 46 0 0 0 % P
% Gln: 46 10 0 0 0 0 46 0 0 10 10 0 10 0 10 % Q
% Arg: 10 10 10 0 0 10 0 10 10 55 0 10 55 10 0 % R
% Ser: 10 10 19 46 19 0 0 64 19 10 46 28 10 10 55 % S
% Thr: 10 0 28 0 19 0 10 0 0 0 0 0 10 0 0 % T
% Val: 0 10 10 10 0 46 0 0 0 10 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _