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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2F
All Species:
17.88
Human Site:
S586
Identified Species:
39.33
UniProt:
P51841
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51841
NP_001513.2
1108
124822
S586
G
D
F
G
D
L
K
S
I
K
S
R
A
S
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001098846
1108
125126
S586
G
D
F
G
D
V
K
S
I
K
S
R
A
S
D
Dog
Lupus familis
XP_538138
1108
124925
Y586
G
G
F
G
D
I
K
Y
I
K
S
S
A
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q5SDA5
1108
124407
S586
G
D
F
G
D
I
K
S
I
K
S
S
A
S
D
Rat
Rattus norvegicus
P51842
1108
124393
S586
G
D
F
G
D
I
K
S
I
K
S
S
A
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506097
1100
119406
P610
G
S
S
P
E
L
H
P
E
S
T
S
F
L
R
Chicken
Gallus gallus
XP_417281
1078
121075
Q561
G
A
V
H
H
L
R
Q
S
S
T
S
I
L
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103165
1107
124634
P589
G
T
F
R
S
I
T
P
N
T
S
D
V
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
S571
K
S
V
D
I
T
R
S
I
R
K
E
L
K
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
H599
T
A
K
Y
Q
Y
T
H
L
T
K
A
D
K
E
Sea Urchin
Strong. purpuratus
P16065
1125
126238
R614
I
D
L
T
R
A
V
R
T
E
L
K
I
M
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.5
91.4
N.A.
89.9
89.8
N.A.
51.3
60.7
N.A.
61.9
N.A.
31.5
N.A.
29.5
32.5
Protein Similarity:
100
N.A.
98.1
94.7
N.A.
93.7
93.5
N.A.
67.2
75
N.A.
75.9
N.A.
48.6
N.A.
47.9
50.4
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
86.6
86.6
N.A.
13.3
13.3
N.A.
20
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
N.A.
100
80
N.A.
93.3
93.3
N.A.
26.6
26.6
N.A.
33.3
N.A.
26.6
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
0
0
10
0
0
0
0
0
10
46
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
46
0
10
46
0
0
0
0
0
0
10
10
0
46
% D
% Glu:
0
0
0
0
10
0
0
0
10
10
0
10
0
0
19
% E
% Phe:
0
0
55
0
0
0
0
0
0
0
0
0
10
10
0
% F
% Gly:
73
10
0
46
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
10
10
0
10
10
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
10
37
0
0
55
0
0
0
19
0
0
% I
% Lys:
10
0
10
0
0
0
46
0
0
46
19
10
0
19
0
% K
% Leu:
0
0
10
0
0
28
0
0
10
0
10
0
10
19
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
19
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
10
0
19
10
0
10
0
19
0
0
28
% R
% Ser:
0
19
10
0
10
0
0
46
10
19
55
46
0
46
0
% S
% Thr:
10
10
0
10
0
10
19
0
10
19
19
0
0
0
0
% T
% Val:
0
0
19
0
0
10
10
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
10
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _