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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKTL1
All Species:
16.97
Human Site:
T273
Identified Species:
33.94
UniProt:
P51854
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51854
NP_001139406.1
596
65333
T273
D
S
P
E
V
N
I
T
D
V
R
M
T
S
P
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
A299
D
A
P
S
V
D
I
A
N
I
R
M
P
S
L
Rhesus Macaque
Macaca mulatta
XP_001090256
596
65251
T273
D
S
P
E
V
N
I
T
D
V
R
M
T
S
P
Dog
Lupus familis
XP_538204
596
64805
L273
D
S
P
P
V
N
I
L
D
I
E
M
A
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4D4
627
68429
S304
D
S
P
R
I
S
M
S
N
T
K
M
T
S
L
Rat
Rattus norvegicus
P50137
623
67625
A299
D
A
P
S
V
D
I
A
N
I
R
M
P
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
K401
D
A
P
V
V
N
I
K
N
I
R
M
S
S
P
Chicken
Gallus gallus
XP_414333
627
68436
R299
D
A
P
V
V
N
I
R
N
I
K
M
P
S
P
Frog
Xenopus laevis
NP_001079885
625
67433
S302
D
A
P
K
I
S
I
S
G
I
A
F
P
S
P
Zebra Danio
Brachydanio rerio
NP_932336
625
67820
S302
D
A
P
P
A
D
L
S
P
I
H
L
L
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
S342
D
D
A
A
T
L
K
S
I
I
T
G
E
L
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
Y349
W
E
S
K
L
P
T
Y
T
A
K
D
S
A
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.5
96.6
79.8
N.A.
70.4
59
N.A.
51.7
60.9
63.5
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
74.3
98.6
92.4
N.A.
83.2
74.9
N.A.
64.5
74.6
79.8
78
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
100
66.6
N.A.
40
46.6
N.A.
60
53.3
33.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
73.3
100
73.3
N.A.
80
80
N.A.
86.6
80
73.3
60
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
20.7
N.A.
N.A.
20.4
N.A.
Protein Similarity:
N.A.
38.3
N.A.
N.A.
38.9
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
9
9
9
0
0
17
0
9
9
0
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
92
9
0
0
0
25
0
0
25
0
0
9
0
0
0
% D
% Glu:
0
9
0
17
0
0
0
0
0
0
9
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
17
0
67
0
9
67
0
0
0
0
0
% I
% Lys:
0
0
0
17
0
0
9
9
0
0
25
0
0
0
0
% K
% Leu:
0
0
0
0
9
9
9
9
0
0
0
9
9
9
17
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
67
0
0
0
% M
% Asn:
0
0
0
0
0
42
0
0
42
0
0
0
0
0
0
% N
% Pro:
0
0
84
17
0
9
0
0
9
0
0
0
34
0
67
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
9
0
0
0
9
0
0
42
0
0
0
0
% R
% Ser:
0
34
9
17
0
17
0
34
0
0
0
0
17
67
0
% S
% Thr:
0
0
0
0
9
0
9
17
9
9
9
0
25
17
0
% T
% Val:
0
0
0
17
59
0
0
0
0
17
0
0
0
0
9
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _