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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TKTL1 All Species: 38.79
Human Site: Y537 Identified Species: 77.58
UniProt: P51854 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51854 NP_001139406.1 596 65333 Y537 I I T V E D H Y P Q G G I G E
Chimpanzee Pan troglodytes Q5R1W6 623 67821 Y563 I L T V E D H Y Y E G G I G E
Rhesus Macaque Macaca mulatta XP_001090256 596 65251 Y537 I I T V E D H Y P Q G G I G E
Dog Lupus familis XP_538204 596 64805 Y537 I I T V E D H Y P E G G I G E
Cat Felis silvestris
Mouse Mus musculus Q9D4D4 627 68429 Y568 I I T V E D H Y R E G G I G E
Rat Rattus norvegicus P50137 623 67625 Y563 I L T V E D H Y Y E G G I G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508404 725 77819 Y665 I L T V E D H Y Y E G G I G E
Chicken Gallus gallus XP_414333 627 68436 Y563 I I T V E D H Y H E G G I G E
Frog Xenopus laevis NP_001079885 625 67433 Y566 I I T V E D H Y R E G G I G E
Zebra Danio Brachydanio rerio NP_932336 625 67820 Y566 V I T V E D H Y K E G G L G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q7SIC9 675 72975 V618 E S V L P A A V T A R I S I E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23254 680 73787 V617 V P I M S V E V L A T T C W G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.5 96.6 79.8 N.A. 70.4 59 N.A. 51.7 60.9 63.5 60.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 74.3 98.6 92.4 N.A. 83.2 74.9 N.A. 64.5 74.6 79.8 78 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 80 100 93.3 N.A. 86.6 80 N.A. 80 86.6 86.6 73.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 100 100 N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. 20.7 N.A. N.A. 20.4 N.A.
Protein Similarity: N.A. 38.3 N.A. N.A. 38.9 N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 13.3 N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 9 0 0 17 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % C
% Asp: 0 0 0 0 0 84 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 0 0 0 84 0 9 0 0 67 0 0 0 0 92 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 84 84 0 84 9 % G
% His: 0 0 0 0 0 0 84 0 9 0 0 0 0 0 0 % H
% Ile: 75 59 9 0 0 0 0 0 0 0 0 9 75 9 0 % I
% Lys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % K
% Leu: 0 25 0 9 0 0 0 0 9 0 0 0 9 0 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 0 0 9 0 0 0 25 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 17 0 9 0 0 0 0 % R
% Ser: 0 9 0 0 9 0 0 0 0 0 0 0 9 0 0 % S
% Thr: 0 0 84 0 0 0 0 0 9 0 9 9 0 0 0 % T
% Val: 17 0 9 84 0 9 0 17 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % W
% Tyr: 0 0 0 0 0 0 0 84 25 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _