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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AKR1D1 All Species: 27.88
Human Site: T105 Identified Species: 68.15
UniProt: P51857 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51857 NP_005980.1 326 37377 T105 V R P T L E R T L R V L Q L D
Chimpanzee Pan troglodytes XP_001148543 262 30135 I68 E H E V G E A I R E K I A E G
Rhesus Macaque Macaca mulatta XP_001107157 326 37350 T105 V R P T L E R T L R V L Q L D
Dog Lupus familis XP_539827 341 38742 T133 V R P T L E K T L S V L Q L D
Cat Felis silvestris
Mouse Mus musculus Q8VCX1 325 37271 T104 V L P A L E R T L K A L K L D
Rat Rattus norvegicus P31210 326 37359 T104 V R P A L E R T L Q T L K L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511338 324 36611 S103 V R K A L E I S L R R L Q L D
Chicken Gallus gallus XP_416341 448 49517 T227 V R P T L E K T L K I L Q L D
Frog Xenopus laevis NP_001083618 304 35088 Y95 Q L D Y V D L Y I I E L P M A
Zebra Danio Brachydanio rerio Q6AZW2 324 36744 S97 V E E A C R R S L S D L R L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.3 98.7 85.3 N.A. 82.5 79.7 N.A. 59.2 60.2 73.9 47.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 80.3 99.3 88.2 N.A. 90.1 89.5 N.A. 76.3 68.7 83.1 64.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 86.6 N.A. 66.6 73.3 N.A. 66.6 80 6.6 33.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 93.3 N.A. 80 86.6 N.A. 73.3 100 33.3 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 40 0 0 10 0 0 0 10 0 10 0 10 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 10 0 0 0 0 10 0 0 0 70 % D
% Glu: 10 10 20 0 0 80 0 0 0 10 10 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 10 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 10 10 10 10 10 0 0 0 % I
% Lys: 0 0 10 0 0 0 20 0 0 20 10 0 20 0 0 % K
% Leu: 0 20 0 0 70 0 10 0 80 0 0 90 0 80 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 60 0 0 0 0 0 0 0 0 0 10 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 10 0 0 50 0 0 % Q
% Arg: 0 60 0 0 0 10 50 0 10 30 10 0 10 0 0 % R
% Ser: 0 0 0 0 0 0 0 20 0 20 0 0 0 0 10 % S
% Thr: 0 0 0 40 0 0 0 60 0 0 10 0 0 0 0 % T
% Val: 80 0 0 10 10 0 0 0 0 0 30 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _