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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR1D1
All Species:
28.48
Human Site:
T254
Identified Species:
69.63
UniProt:
P51857
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51857
NP_005980.1
326
37377
T254
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
Chimpanzee
Pan troglodytes
XP_001148543
262
30135
K209
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
Rhesus Macaque
Macaca mulatta
XP_001107157
326
37350
T254
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
Dog
Lupus familis
XP_539827
341
38742
T282
L
G
K
K
Y
K
K
T
A
A
Q
I
V
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCX1
325
37271
T253
L
G
K
K
Y
N
K
T
Q
A
Q
I
V
L
R
Rat
Rattus norvegicus
P31210
326
37359
T254
L
G
K
K
Y
N
K
T
Q
A
Q
I
V
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511338
324
36611
T252
I
A
K
K
H
N
R
T
P
A
L
V
A
L
R
Chicken
Gallus gallus
XP_416341
448
49517
T376
I
G
K
K
Y
N
K
T
A
A
Q
V
A
L
R
Frog
Xenopus laevis
NP_001083618
304
35088
V236
Y
N
K
T
A
A
Q
V
A
L
R
F
N
A
Q
Zebra Danio
Brachydanio rerio
Q6AZW2
324
36744
T243
I
A
K
S
Y
N
K
T
P
A
Q
V
I
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80.3
98.7
85.3
N.A.
82.5
79.7
N.A.
59.2
60.2
73.9
47.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
80.3
99.3
88.2
N.A.
90.1
89.5
N.A.
76.3
68.7
83.1
64.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
86.6
N.A.
86.6
86.6
N.A.
40
73.3
13.3
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
93.3
N.A.
93.3
93.3
N.A.
73.3
93.3
33.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
0
10
10
0
0
50
80
0
0
20
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% F
% Gly:
0
70
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
30
0
0
0
0
10
0
0
0
0
0
50
10
10
10
% I
% Lys:
0
0
90
50
0
10
70
10
0
0
0
0
0
0
0
% K
% Leu:
50
0
0
0
0
0
0
0
0
10
10
10
0
70
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
70
0
0
0
0
10
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
10
0
20
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
20
0
70
0
0
0
10
% Q
% Arg:
10
0
0
20
0
0
10
0
0
0
10
0
0
10
80
% R
% Ser:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% S
% Thr:
0
0
0
10
0
0
0
80
0
0
0
0
0
0
0
% T
% Val:
0
0
10
10
10
0
0
10
0
0
0
30
50
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _