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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
31.21
Human Site:
S378
Identified Species:
49.05
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S378
E
L
L
N
L
P
S
S
V
I
K
K
K
V
H
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S455
E
L
L
N
L
P
S
S
V
I
K
K
K
V
H
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S378
E
L
L
N
L
P
S
S
V
I
K
K
K
V
H
Dog
Lupus familis
XP_537144
668
75595
S601
E
L
F
D
L
P
S
S
I
I
K
K
K
V
H
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
S377
P
E
L
D
L
P
S
S
A
M
K
K
K
V
H
Rat
Rattus norvegicus
XP_001055166
443
51340
S377
S
E
L
D
L
P
S
S
A
L
K
K
K
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
S432
D
E
P
L
D
L
P
S
T
I
T
K
K
K
V
Chicken
Gallus gallus
NP_001026221
444
51581
F377
D
N
A
L
L
L
P
F
S
T
T
K
K
K
V
Frog
Xenopus laevis
NP_001079490
442
52004
G370
F
Q
A
A
L
E
N
G
I
D
A
Y
T
E
S
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
T519
D
C
S
M
I
M
S
T
Q
H
Q
I
L
A
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
S447
H
A
I
R
A
Q
E
S
L
L
Q
Q
K
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
S345
R
L
V
K
D
K
M
S
R
A
E
E
L
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
S532
A
G
A
S
S
R
A
S
S
G
V
R
R
Q
R
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
D340
S
T
F
E
L
L
Q
D
I
Q
I
R
T
A
R
Red Bread Mold
Neurospora crassa
P48479
858
94329
S486
P
I
T
I
A
S
L
S
L
S
P
R
R
M
A
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
100
80
N.A.
66.6
66.6
N.A.
26.6
20
6.6
6.6
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
80
80
N.A.
33.3
26.6
20
33.3
N.A.
53.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
20
7
14
0
7
0
14
7
7
0
0
14
7
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
20
0
0
20
14
0
0
7
0
7
0
0
0
0
0
% D
% Glu:
27
20
0
7
0
7
7
0
0
0
7
7
0
7
14
% E
% Phe:
7
0
14
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
7
0
7
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
40
% H
% Ile:
0
7
7
7
7
0
0
0
20
34
7
7
0
7
0
% I
% Lys:
0
0
0
7
0
7
0
0
0
0
40
54
60
14
0
% K
% Leu:
0
34
34
14
60
20
7
0
14
14
0
0
14
7
0
% L
% Met:
0
0
0
7
0
7
7
0
0
7
0
0
0
7
0
% M
% Asn:
0
7
0
20
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
14
0
7
0
0
40
14
0
0
0
7
0
0
0
0
% P
% Gln:
0
7
0
0
0
7
7
0
7
7
14
7
0
7
0
% Q
% Arg:
7
0
0
7
0
7
0
0
7
0
0
20
14
0
14
% R
% Ser:
14
0
7
7
7
7
47
74
14
7
0
0
0
0
7
% S
% Thr:
0
7
7
0
0
0
0
7
7
7
14
0
14
0
0
% T
% Val:
0
0
7
0
0
0
0
0
20
0
7
0
0
40
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _