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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEK2 All Species: 33.94
Human Site: T136 Identified Species: 53.33
UniProt: P51955 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51955 NP_002488.1 445 51763 T136 R R S D G G H T V L H R D L K
Chimpanzee Pan troglodytes XP_514178 522 59597 T213 R R S D G G H T V L H R D L K
Rhesus Macaque Macaca mulatta XP_001108740 445 51674 T136 R R S D G G H T V L H R D L K
Dog Lupus familis XP_537144 668 75595 T360 R R S D G G H T V L H R D L K
Cat Felis silvestris
Mouse Mus musculus O35942 443 51289 T136 R R S D G G H T V L H R D L K
Rat Rattus norvegicus XP_001055166 443 51340 T136 R R S D G G H T V L H R D L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509538 499 57433 T190 R R S D S G H T V L H R D L K
Chicken Gallus gallus NP_001026221 444 51581 T136 R R S D G G V T V H R D L K P
Frog Xenopus laevis NP_001079490 442 52004 T136 K R S D G G H T V L H R D L K
Zebra Danio Brachydanio rerio Q90XC2 697 76523 K138 T Q N I L L D K H Q M I V K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572415 735 82962 I147 N K I P N G T I L H R D I K P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786794 453 51921 I136 R R G K G R A I L H R D L K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9CAU7 606 68016 L137 V K C S N I F L T K D Q D I R
Baker's Yeast Sacchar. cerevisiae P22209 435 51185 L153 Y G V E L P T L T T I Y D R M
Red Bread Mold Neurospora crassa P48479 858 94329 V135 Y G V D P P E V G K T V L G L
Conservation
Percent
Protein Identity: 100 85 98.4 62.5 N.A. 87.6 89.4 N.A. 69.7 77 73.9 25.8 N.A. 30.2 N.A. N.A. 54.3
Protein Similarity: 100 85 99.3 65.4 N.A. 94.1 95 N.A. 80.9 88.7 86.7 39 N.A. 44.3 N.A. N.A. 72.1
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 53.3 93.3 0 N.A. 6.6 N.A. N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 53.3 100 13.3 N.A. 20 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 27.2 22.7 24.3
Protein Similarity: N.A. N.A. N.A. 44.8 43.8 36.1
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 67 0 0 7 0 0 0 7 20 67 0 0 % D
% Glu: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 0 14 7 0 60 67 0 0 7 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 54 0 7 20 54 0 0 0 0 % H
% Ile: 0 0 7 7 0 7 0 14 0 0 7 7 7 7 7 % I
% Lys: 7 14 0 7 0 0 0 7 0 14 0 0 0 27 54 % K
% Leu: 0 0 0 0 14 7 0 14 14 54 0 0 20 54 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % M
% Asn: 7 0 7 0 14 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 7 14 0 0 0 0 0 0 0 0 20 % P
% Gln: 0 7 0 0 0 0 0 0 0 7 0 7 0 0 0 % Q
% Arg: 60 67 0 0 0 7 0 0 0 0 20 54 0 7 7 % R
% Ser: 0 0 60 7 7 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 7 0 0 0 0 0 14 60 14 7 7 0 0 0 0 % T
% Val: 7 0 14 0 0 0 7 7 60 0 0 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 14 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _