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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
44.24
Human Site:
Y71
Identified Species:
69.52
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
Y71
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Chimpanzee
Pan troglodytes
XP_514178
522
59597
Y148
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
Y71
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Dog
Lupus familis
XP_537144
668
75595
Y295
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
Y71
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Rat
Rattus norvegicus
XP_001055166
443
51340
Y71
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
Y125
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Chicken
Gallus gallus
NP_001026221
444
51581
H71
H
P
N
I
V
R
Y
H
D
R
I
I
D
R
S
Frog
Xenopus laevis
NP_001079490
442
52004
Y71
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
D73
Y
Y
E
N
F
L
E
D
K
A
L
M
I
A
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
Y82
H
P
N
I
V
Q
Y
Y
H
H
L
V
N
R
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
Y71
H
E
F
I
V
R
Y
Y
D
R
I
V
D
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
E72
E
Y
K
D
S
W
V
E
K
G
C
Y
V
C
I
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
Y88
H
E
N
I
V
E
F
Y
N
W
D
F
D
E
Q
Red Bread Mold
Neurospora crassa
P48479
858
94329
Y70
H
P
N
I
V
G
Y
Y
H
R
E
H
L
K
A
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
86.6
100
0
N.A.
53.3
N.A.
N.A.
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
20
N.A.
80
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
0
40
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
0
53.3
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% C
% Asp:
0
0
0
7
0
0
0
7
67
0
7
0
74
0
0
% D
% Glu:
7
14
7
0
0
7
7
7
0
0
7
0
0
7
7
% E
% Phe:
0
0
7
0
7
0
7
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% G
% His:
87
0
0
0
0
0
0
7
14
7
0
7
0
0
0
% H
% Ile:
0
0
0
87
0
0
0
0
0
0
67
60
7
0
7
% I
% Lys:
0
0
7
0
0
0
0
0
14
0
0
0
0
7
0
% K
% Leu:
0
0
0
0
0
7
0
0
0
0
14
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% M
% Asn:
0
0
80
7
0
0
0
0
7
0
0
0
7
0
0
% N
% Pro:
0
74
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
0
67
0
0
0
74
0
0
0
74
0
% R
% Ser:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% T
% Val:
0
0
0
0
87
0
7
0
0
0
0
14
7
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% W
% Tyr:
7
14
0
0
0
0
80
80
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _