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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
JAK3
All Species:
15.45
Human Site:
S143
Identified Species:
34
UniProt:
P52333
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52333
NP_000206.2
1124
125099
S143
H
L
F
A
Q
H
R
S
D
L
V
S
G
R
L
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
Rhesus Macaque
Macaca mulatta
XP_001115037
954
105707
L72
M
A
K
Y
I
M
D
L
E
R
L
D
P
A
G
Dog
Lupus familis
XP_852473
1103
122784
N143
H
L
F
A
Q
H
R
N
D
L
V
S
G
R
F
Cat
Felis silvestris
Mouse
Mus musculus
Q62137
1100
122623
S143
H
L
F
A
Q
H
R
S
D
L
V
S
G
R
L
Rat
Rattus norvegicus
Q63272
1100
122542
S143
H
L
F
A
Q
H
R
S
D
L
V
S
G
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505937
950
110363
S68
R
A
Y
R
H
G
I
S
R
G
S
E
A
P
L
Chicken
Gallus gallus
Q75R65
1129
129828
K157
Y
L
F
A
Q
W
R
K
D
F
L
D
G
W
I
Frog
Xenopus laevis
NP_001085288
1129
130564
D157
Y
L
F
A
Q
W
R
D
D
F
V
N
G
R
I
Zebra Danio
Brachydanio rerio
O12990
1153
132463
Y162
Y
L
F
A
Q
G
Q
Y
D
F
L
R
G
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24592
1177
135043
Y154
F
L
Y
R
Q
M
R
Y
D
M
R
T
E
Q
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.5
83
88.6
N.A.
82.3
80
N.A.
42.7
50.1
48.7
39
N.A.
22.6
N.A.
N.A.
N.A.
Protein Similarity:
100
35.9
83.3
92
N.A.
87.9
86.3
N.A.
59
68.1
66.8
57.3
N.A.
40.7
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
86.6
N.A.
100
100
N.A.
13.3
46.6
60
40
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
0
13.3
93.3
N.A.
100
100
N.A.
20
66.6
80
60
N.A.
60
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
64
0
0
0
0
0
0
0
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
10
73
0
0
19
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
10
10
0
0
% E
% Phe:
10
0
64
0
0
0
0
0
0
28
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
19
0
0
0
10
0
0
64
0
10
% G
% His:
37
0
0
0
10
37
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
28
% I
% Lys:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
0
73
0
0
0
0
0
10
0
37
28
0
0
10
37
% L
% Met:
10
0
0
0
0
19
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% P
% Gln:
0
0
0
0
73
0
10
0
0
0
0
0
0
10
0
% Q
% Arg:
10
0
0
19
0
0
64
0
10
10
10
10
0
46
0
% R
% Ser:
0
0
0
0
0
0
0
37
0
0
10
37
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
46
0
0
0
0
% V
% Trp:
0
0
0
0
0
19
0
0
0
0
0
0
0
10
0
% W
% Tyr:
28
0
19
10
0
0
0
19
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _