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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
JAK3
All Species:
11.52
Human Site:
S531
Identified Species:
25.33
UniProt:
P52333
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52333
NP_000206.2
1124
125099
S531
H
E
N
L
G
H
G
S
F
T
K
I
Y
R
G
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
N288
T
L
T
C
I
A
E
N
V
V
G
M
S
N
A
Rhesus Macaque
Macaca mulatta
XP_001115037
954
105707
L416
V
S
Y
R
H
L
V
L
L
H
G
V
C
M
A
Dog
Lupus familis
XP_852473
1103
122784
S531
H
E
N
L
G
H
G
S
F
T
K
I
Y
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62137
1100
122623
F528
E
N
L
G
H
G
S
F
T
K
I
F
R
G
R
Rat
Rattus norvegicus
Q63272
1100
122542
F528
E
N
L
G
H
G
S
F
T
K
I
F
H
G
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505937
950
110363
Y412
L
K
D
L
L
N
C
Y
Q
M
E
T
V
R
S
Chicken
Gallus gallus
Q75R65
1129
129828
F553
E
S
L
G
Q
G
T
F
T
K
I
F
K
G
I
Frog
Xenopus laevis
NP_001085288
1129
130564
T553
L
E
N
L
G
Q
G
T
F
T
K
I
F
K
G
Zebra Danio
Brachydanio rerio
O12990
1153
132463
A596
G
T
R
T
N
I
Y
A
G
I
L
K
P
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24592
1177
135043
S589
Y
P
D
S
I
S
L
S
D
D
G
M
M
F
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.5
83
88.6
N.A.
82.3
80
N.A.
42.7
50.1
48.7
39
N.A.
22.6
N.A.
N.A.
N.A.
Protein Similarity:
100
35.9
83.3
92
N.A.
87.9
86.3
N.A.
59
68.1
66.8
57.3
N.A.
40.7
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
100
N.A.
0
0
N.A.
13.3
0
66.6
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
6.6
100
N.A.
0
6.6
N.A.
40
0
86.6
13.3
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
19
% A
% Cys:
0
0
0
10
0
0
10
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
19
0
0
0
0
0
10
10
0
0
0
0
0
% D
% Glu:
28
28
0
0
0
0
10
0
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
28
28
0
0
28
10
10
0
% F
% Gly:
10
0
0
28
28
28
28
0
10
0
28
0
0
28
28
% G
% His:
19
0
0
0
28
19
0
0
0
10
0
0
10
0
10
% H
% Ile:
0
0
0
0
19
10
0
0
0
10
28
28
0
0
10
% I
% Lys:
0
10
0
0
0
0
0
0
0
28
28
10
10
19
0
% K
% Leu:
19
10
28
37
10
10
10
10
10
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
19
10
10
0
% M
% Asn:
0
19
28
0
10
10
0
10
0
0
0
0
0
10
0
% N
% Pro:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
10
10
0
0
10
0
0
0
0
0
0
% Q
% Arg:
0
0
10
10
0
0
0
0
0
0
0
0
10
28
10
% R
% Ser:
0
19
0
10
0
10
19
28
0
0
0
0
10
0
19
% S
% Thr:
10
10
10
10
0
0
10
10
28
28
0
10
0
0
10
% T
% Val:
10
0
0
0
0
0
10
0
10
10
0
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
0
10
10
0
0
0
0
19
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _