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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2H All Species: 24.55
Human Site: S105 Identified Species: 41.54
UniProt: P52434 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52434 NP_006223.2 150 17143 S105 R I E G D E T S T E A A T R L
Chimpanzee Pan troglodytes XP_526411 122 13830 S84 P T D D R P S S S A Y V S Y G
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus XP_996451 150 17237 S105 R I E G D E T S T E A A T R L
Rat Rattus norvegicus XP_226176 151 17092 S106 R I E G D E S S T E A A T C L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232695 122 13865 L84 S T E A A T R L S A Y V S Y G
Frog Xenopus laevis NP_001085470 150 17139 S105 R I E G D E T S T E A A T R L
Zebra Danio Brachydanio rerio NP_001017600 150 17108 S105 R I E G D E T S T E A A T R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649352 149 17185 H105 R I E G D E A H N E A S R L S
Honey Bee Apis mellifera XP_394557 151 17160 A105 Y R I E G D E A S N E P S S R
Nematode Worm Caenorhab. elegans Q19826 148 16993 T105 L E D D D T G T D G G K L A A
Sea Urchin Strong. purpuratus XP_796332 151 17165 S105 Y R I E G D E S L T E A A T K
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147399 146 16550 S105 I S E D T S S S Q N A K V E M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_175827 146 16493 T107 I S E R D G K T P K A E L Y V
Baker's Yeast Sacchar. cerevisiae P20436 146 16493 F104 M Y G T A Y K F E E V S K D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.3 N.A. N.A. N.A. 96.6 91.3 N.A. N.A. 81.3 97.3 97.3 N.A. 78 77.4 63.3 82.7
Protein Similarity: 100 81.3 N.A. N.A. N.A. 98 94.6 N.A. N.A. 81.3 100 98.6 N.A. 88.6 87.4 80.6 90.7
P-Site Identity: 100 6.6 N.A. N.A. N.A. 100 86.6 N.A. N.A. 6.6 100 100 N.A. 53.3 0 6.6 13.3
P-Site Similarity: 100 33.3 N.A. N.A. N.A. 100 93.3 N.A. N.A. 20 100 100 N.A. 60 26.6 20 20
Percent
Protein Identity: N.A. 46.6 N.A. 48 36.6 N.A.
Protein Similarity: N.A. 64.6 N.A. 68.6 58.6 N.A.
P-Site Identity: N.A. 20 N.A. 20 13.3 N.A.
P-Site Similarity: N.A. 33.3 N.A. 40 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 15 0 8 8 0 15 58 43 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 15 22 58 15 0 0 8 0 0 0 0 8 0 % D
% Glu: 0 8 65 15 0 43 15 0 8 50 15 8 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 43 15 8 8 0 0 8 8 0 0 0 15 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 15 43 15 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 15 0 0 8 0 15 8 0 8 % K
% Leu: 8 0 0 0 0 0 0 8 8 0 0 0 15 8 43 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 8 15 0 0 0 0 0 % N
% Pro: 8 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 43 15 0 8 8 0 8 0 0 0 0 0 8 29 8 % R
% Ser: 8 15 0 0 0 8 22 58 22 0 0 15 22 8 8 % S
% Thr: 0 15 0 8 8 15 29 15 36 8 0 0 36 8 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 8 15 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 8 0 0 0 8 0 0 0 0 15 0 0 22 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _