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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
17.88
Human Site:
S174
Identified Species:
32.78
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
S174
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
K185
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
S174
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
S174
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
G238
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S190
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
Chicken
Gallus gallus
Q90891
398
44059
Q187
A
Y
L
R
E
K
H
Q
I
M
H
R
D
V
K
Frog
Xenopus laevis
Q07192
446
50082
K271
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S201
E
H
L
H
S
N
L
S
V
I
H
R
D
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
K167
H
Y
L
H
A
Q
L
K
V
I
H
R
D
V
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
K189
D
Y
L
K
K
E
L
K
I
I
H
R
D
V
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
H187
I
Y
L
H
H
D
R
H
I
I
H
R
D
L
K
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
N480
K
E
L
K
E
Q
H
N
I
I
H
R
D
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
40
N.A.
100
N.A.
100
60
N.A.
100
46.6
53.3
93.3
N.A.
66.6
N.A.
53.3
N.A.
P-Site Similarity:
100
66.6
N.A.
100
N.A.
100
66.6
N.A.
100
66.6
66.6
93.3
N.A.
86.6
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
8
0
0
0
0
0
0
100
0
0
% D
% Glu:
39
8
0
0
39
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
8
47
0
54
8
0
31
8
0
0
100
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
47
85
0
0
0
8
0
% I
% Lys:
8
0
0
31
8
54
0
31
0
0
0
0
0
0
93
% K
% Leu:
0
0
100
0
0
0
62
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
16
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
16
0
8
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
16
0
0
8
0
0
0
0
100
0
0
0
% R
% Ser:
0
0
0
0
39
0
0
39
0
0
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
54
0
0
0
0
85
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _