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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K6 All Species: 19.09
Human Site: T25 Identified Species: 35
UniProt: P52564 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52564 NP_002749.2 334 37492 T25 E A F E Q P Q T S S T P P R D
Chimpanzee Pan troglodytes Q9XT09 393 43428 L40 L Q K K L E E L E L D E Q Q R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851023 334 37590 T25 E A F E Q P Q T S S T P P R D
Cat Felis silvestris
Mouse Mus musculus P70236 334 37414 T25 E A F E Q P Q T S S T P P R D
Rat Rattus norvegicus Q4KSH7 419 47517 T66 E S S P Q H P T P P S R P R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511595 352 40240 S41 V T I K P P V S N P T P P R N
Chicken Gallus gallus Q90891 398 44059 L42 L Q K K L E E L E L D E Q Q K
Frog Xenopus laevis Q07192 446 50082 T94 D A I R K L E T S Y Q K Q D L
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 P52 E V F E K P A P A P T P P R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477162 334 38176 N25 A A I V P P R N L D S R A T I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20347 363 41178 L45 E E S V L R S L S T G T L K Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7U9 363 39830 T27 Q S I T K F L T Q S G T F K D
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 S119 S Q V V Q A S S K S T L K N V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32 N.A. 98.8 N.A. 97.9 38.6 N.A. 75.2 34.4 43.5 80.6 N.A. 58.6 N.A. 38.2 N.A.
Protein Similarity: 100 47.8 N.A. 99 N.A. 99 53.7 N.A. 85.5 51.5 56 85.8 N.A. 74.8 N.A. 56.2 N.A.
P-Site Identity: 100 0 N.A. 100 N.A. 100 33.3 N.A. 33.3 0 20 60 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 20 N.A. 100 N.A. 100 46.6 N.A. 60 20 40 73.3 N.A. 26.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.9 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. 53.1 36 N.A.
P-Site Identity: N.A. N.A. N.A. 20 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 39 0 0 0 8 8 0 8 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 8 16 0 0 8 39 % D
% Glu: 47 8 0 31 0 16 24 0 16 0 0 16 0 0 0 % E
% Phe: 0 0 31 0 0 8 0 0 0 0 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 16 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 31 0 0 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 16 24 24 0 0 0 8 0 0 8 8 16 8 % K
% Leu: 16 0 0 0 24 8 8 24 8 16 0 8 8 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 8 0 0 0 0 8 8 % N
% Pro: 0 0 0 8 16 47 8 8 8 24 0 39 47 0 0 % P
% Gln: 8 24 0 0 39 0 24 0 8 0 8 0 24 16 0 % Q
% Arg: 0 0 0 8 0 8 8 0 0 0 0 16 0 47 8 % R
% Ser: 8 16 16 0 0 0 16 16 39 39 16 0 0 0 0 % S
% Thr: 0 8 0 8 0 0 0 47 0 8 47 16 0 8 0 % T
% Val: 8 8 8 24 0 0 8 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _