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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
14.55
Human Site:
T322
Identified Species:
26.67
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
T322
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
V369
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
T322
T
L
H
E
S
K
A
T
D
V
A
S
F
V
K
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
A322
T
V
H
E
S
K
A
A
D
V
A
S
F
V
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
E387
I
K
H
Y
E
T
L
E
V
D
V
A
S
W
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
T338
N
L
H
K
T
K
E
T
D
I
A
A
F
V
I
Chicken
Gallus gallus
Q90891
398
44059
V375
K
R
S
E
V
E
E
V
D
F
A
G
W
L
C
Frog
Xenopus laevis
Q07192
446
50082
E419
P
F
I
L
M
Y
E
E
R
T
V
D
V
A
G
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
T349
T
L
H
D
S
K
D
T
D
V
A
S
F
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
T315
V
E
H
L
Q
R
N
T
D
I
S
E
F
V
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
G337
Y
R
I
Y
A
V
A
G
P
E
I
E
E
A
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
I338
N
K
Y
D
Y
S
G
I
N
L
A
S
Y
F
T
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
V631
V
K
Y
R
N
Q
D
V
H
M
S
E
Y
I
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
13.3
N.A.
93.3
N.A.
80
6.6
N.A.
53.3
20
0
86.6
N.A.
33.3
N.A.
6.6
N.A.
P-Site Similarity:
100
46.6
N.A.
93.3
N.A.
86.6
13.3
N.A.
80
40
0
93.3
N.A.
53.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
0
24
8
0
0
62
16
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% C
% Asp:
0
0
0
24
0
0
16
0
62
8
0
8
0
0
0
% D
% Glu:
0
8
0
31
8
16
31
16
0
8
0
24
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
16
0
0
47
8
8
% F
% Gly:
0
0
0
0
0
0
16
8
0
0
0
16
0
0
8
% G
% His:
0
0
54
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
16
0
0
0
0
8
0
16
8
0
0
8
8
% I
% Lys:
16
24
0
8
0
39
0
0
0
0
0
0
0
0
39
% K
% Leu:
0
31
0
16
0
0
8
0
0
8
0
0
0
16
0
% L
% Met:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
16
0
0
0
8
0
8
0
8
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
24
0
8
0
8
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
16
0
31
8
0
0
0
0
16
39
8
0
0
% S
% Thr:
31
0
0
0
8
8
0
39
0
8
0
0
0
0
16
% T
% Val:
16
8
0
0
8
8
0
24
8
31
16
0
8
47
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
16
8
0
% W
% Tyr:
8
0
16
16
8
8
0
0
0
0
0
0
16
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _