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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
16.67
Human Site:
S126
Identified Species:
26.19
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S126
F
I
R
E
K
G
K
S
V
R
V
H
V
Q
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S126
F
I
R
E
K
G
K
S
V
R
V
H
V
Q
F
Dog
Lupus familis
XP_531814
1283
145094
E127
E
P
S
E
P
E
E
E
E
E
M
E
V
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S126
F
I
R
K
K
G
K
S
V
R
V
H
V
Q
F
Rat
Rattus norvegicus
XP_002726765
1361
151628
R126
R
K
N
G
K
S
A
R
V
H
V
Q
F
F
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S241
I
V
R
G
K
G
S
S
A
R
I
H
V
Q
F
Frog
Xenopus laevis
NP_001089247
1340
149481
S126
H
V
Q
F
F
D
D
S
P
T
R
G
W
T
G
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
V126
G
R
D
Q
R
L
H
V
H
F
F
D
E
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
N49
A
S
K
S
E
K
E
N
L
Q
N
Q
Q
P
K
Honey Bee
Apis mellifera
XP_392346
1120
127429
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
N45
N
D
T
P
K
I
S
N
D
S
E
K
K
V
L
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S126
F
I
E
G
Y
N
G
S
R
A
K
E
C
Q
F
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
S128
V
K
S
Y
D
D
E
S
K
K
H
L
I
Q
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
G126
T
Y
G
D
E
V
V
G
K
Q
V
R
V
Y
W
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
H101
T
V
R
S
D
I
M
H
S
Q
E
P
Q
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
93.3
20
N.A.
N.A.
60
6.6
0
N.A.
0
0
6.6
33.3
P-Site Similarity:
100
N.A.
100
26.6
N.A.
100
20
N.A.
N.A.
73.3
20
13.3
N.A.
40
0
13.3
33.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
40
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
7
0
7
7
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
7
7
7
14
14
7
0
7
0
0
7
0
0
14
% D
% Glu:
7
0
7
20
14
7
20
7
7
7
14
14
7
0
0
% E
% Phe:
27
0
0
7
7
0
0
0
0
7
7
0
7
7
34
% F
% Gly:
7
0
7
20
0
27
7
7
0
0
0
7
0
7
7
% G
% His:
7
0
0
0
0
0
7
7
7
7
7
27
0
0
0
% H
% Ile:
7
27
0
0
0
14
0
0
0
0
7
0
7
0
0
% I
% Lys:
0
14
7
7
40
7
20
0
14
7
7
7
7
0
7
% K
% Leu:
0
0
0
0
0
7
0
0
7
0
0
7
0
0
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
7
0
0
7
0
14
0
0
7
0
0
0
0
% N
% Pro:
0
7
0
7
7
0
0
0
7
0
0
7
0
14
7
% P
% Gln:
0
0
7
7
0
0
0
0
0
20
0
14
14
40
0
% Q
% Arg:
7
7
34
0
7
0
0
7
7
27
7
7
0
0
0
% R
% Ser:
0
7
14
14
0
7
14
47
7
7
0
0
0
7
0
% S
% Thr:
14
0
7
0
0
0
0
0
0
7
0
0
0
7
0
% T
% Val:
7
20
0
0
0
7
7
7
27
0
34
0
40
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% W
% Tyr:
0
7
0
7
7
0
0
0
0
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _