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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
20
Human Site:
S252
Identified Species:
31.43
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S252
I
K
K
R
R
V
I
S
D
S
E
S
D
I
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S252
I
K
K
R
R
V
I
S
D
S
E
S
D
I
G
Dog
Lupus familis
XP_531814
1283
145094
K235
G
N
G
S
L
K
R
K
S
S
R
K
E
M
P
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S252
V
K
K
R
R
V
I
S
D
S
E
S
D
I
G
Rat
Rattus norvegicus
XP_002726765
1361
151628
S255
V
K
K
R
R
V
I
S
D
S
E
S
D
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
L356
K
A
K
R
R
R
V
L
D
S
D
S
D
R
D
Frog
Xenopus laevis
NP_001089247
1340
149481
S235
R
I
M
I
E
S
D
S
D
N
E
G
S
D
D
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S254
R
I
V
V
A
S
D
S
D
D
S
G
E
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
S157
P
K
K
S
R
K
K
S
K
I
L
N
N
N
N
Honey Bee
Apis mellifera
XP_392346
1120
127429
I87
Q
T
K
K
R
R
L
I
I
P
D
E
E
S
G
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
M153
N
T
P
K
S
V
K
M
A
G
K
S
K
K
V
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S234
R
V
A
S
D
S
E
S
S
G
D
E
F
K
P
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
R242
G
G
K
D
S
R
K
R
K
A
S
G
E
G
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
C235
K
N
V
G
K
E
V
C
E
S
E
E
D
D
V
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
S209
G
D
D
D
D
L
I
S
L
A
E
T
T
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
46.6
20
13.3
N.A.
26.6
20
13.3
6.6
P-Site Similarity:
100
N.A.
100
20
N.A.
100
100
N.A.
N.A.
60
26.6
20
N.A.
40
46.6
26.6
13.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
7
0
0
0
7
14
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
14
14
0
14
0
47
7
20
0
40
14
14
% D
% Glu:
0
0
0
0
7
7
7
0
7
0
47
20
27
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% F
% Gly:
20
7
7
7
0
0
0
0
0
14
0
20
0
7
40
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
14
0
7
0
0
34
7
7
7
0
0
0
27
0
% I
% Lys:
14
34
54
14
7
14
20
7
14
0
7
7
7
14
7
% K
% Leu:
0
0
0
0
7
7
7
7
7
0
7
0
0
0
0
% L
% Met:
0
0
7
0
0
0
0
7
0
0
0
0
0
7
0
% M
% Asn:
7
14
0
0
0
0
0
0
0
7
0
7
7
7
7
% N
% Pro:
7
0
7
0
0
0
0
0
0
7
0
0
0
0
14
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
20
0
0
34
47
20
7
7
0
0
7
0
0
7
0
% R
% Ser:
0
0
0
20
14
20
0
60
14
47
14
40
7
14
0
% S
% Thr:
0
14
0
0
0
0
0
0
0
0
0
7
7
0
0
% T
% Val:
14
7
14
7
0
34
14
0
0
0
0
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _