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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH6 All Species: 20.61
Human Site: S394 Identified Species: 32.38
UniProt: P52701 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52701 NP_000170.1 1360 152786 S394 D H P D F D A S T L Y V P E D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113749 1360 152750 S394 D H P D F N A S T L Y V P E D
Dog Lupus familis XP_531814 1283 145094 E368 D A L T G V N E L G L V F M K
Cat Felis silvestris
Mouse Mus musculus P54276 1358 151058 T393 D H P E F N P T T L Y V P E E
Rat Rattus norvegicus XP_002726765 1361 151628 S396 D H P D Y N S S T L Y V P E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419359 1466 164165 D500 R Q N H P D Y D P C T L Y V P
Frog Xenopus laevis NP_001089247 1340 149481 S373 T D A D Y D P S T L Y I P D D
Zebra Danio Brachydanio rerio NP_878280 1369 153213 T393 S D E N Y D P T T L Y V P E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUM0 1190 133117 E289 F K V G K F Y E L Y H M D A D
Honey Bee Apis mellifera XP_392346 1120 127429 N219 Y V P L D F L N Q Q T P A M R
Nematode Worm Caenorhab. elegans NP_491163 1186 133609 V285 E T Y H M D A V E V V R A L N
Sea Urchin Strong. purpuratus XP_797647 1335 149141 F366 T P T S R K T F G T P S V S S
Poplar Tree Populus trichocarpa XP_002320307 1288 142120 N375 P E K N F S L N V E K L A R K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04716 1324 146779 R367 T D E N Y D P R T L Y L P P D
Baker's Yeast Sacchar. cerevisiae Q03834 1242 140062 Y341 K G K F F E L Y E K D A L L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.3 88.1 N.A. 85.8 86.4 N.A. N.A. 64.2 66.5 60 N.A. 39 41.2 34.4 48.6
Protein Similarity: 100 N.A. 98.6 91.3 N.A. 92.1 92.8 N.A. N.A. 75.4 79.9 74.9 N.A. 57.6 58 52.7 66.6
P-Site Identity: 100 N.A. 93.3 13.3 N.A. 66.6 80 N.A. N.A. 6.6 53.3 53.3 N.A. 6.6 6.6 13.3 0
P-Site Similarity: 100 N.A. 100 13.3 N.A. 93.3 100 N.A. N.A. 13.3 73.3 73.3 N.A. 20 13.3 33.3 0
Percent
Protein Identity: 36.1 N.A. N.A. 33.2 29 N.A.
Protein Similarity: 52 N.A. N.A. 51.4 49.1 N.A.
P-Site Identity: 6.6 N.A. N.A. 40 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 60 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 0 20 0 0 0 0 7 20 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 34 20 0 27 7 40 0 7 0 0 7 0 7 7 47 % D
% Glu: 7 7 14 7 0 7 0 14 14 7 0 0 0 34 7 % E
% Phe: 7 0 0 7 34 14 0 7 0 0 0 0 7 0 0 % F
% Gly: 0 7 0 7 7 0 0 0 7 7 0 0 0 0 0 % G
% His: 0 27 0 14 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 7 7 14 0 7 7 0 0 0 7 7 0 0 0 14 % K
% Leu: 0 0 7 7 0 0 20 0 14 47 7 20 7 14 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 7 0 14 0 % M
% Asn: 0 0 7 20 0 20 7 14 0 0 0 0 0 0 7 % N
% Pro: 7 7 34 0 7 0 27 0 7 0 7 7 47 7 7 % P
% Gln: 0 7 0 0 0 0 0 0 7 7 0 0 0 0 0 % Q
% Arg: 7 0 0 0 7 0 0 7 0 0 0 7 0 7 7 % R
% Ser: 7 0 0 7 0 7 7 27 0 0 0 7 0 7 7 % S
% Thr: 20 7 7 7 0 0 7 14 47 7 14 0 0 0 0 % T
% Val: 0 7 7 0 0 7 0 7 7 7 7 40 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 27 0 14 7 0 7 47 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _