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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
23.33
Human Site:
S580
Identified Species:
36.67
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S580
F
S
D
D
R
H
C
S
R
F
R
T
L
V
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S580
F
S
D
D
R
H
C
S
R
F
R
T
L
V
A
Dog
Lupus familis
XP_531814
1283
145094
K554
S
Q
F
W
D
A
A
K
T
L
R
T
L
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S579
F
S
D
D
R
H
C
S
R
F
R
T
L
V
A
Rat
Rattus norvegicus
XP_002726765
1361
151628
S582
F
S
D
D
R
H
C
S
R
L
R
T
L
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S686
F
S
D
D
R
H
C
S
R
F
R
T
L
V
A
Frog
Xenopus laevis
NP_001089247
1340
149481
S559
F
E
D
D
R
H
C
S
R
F
R
T
L
V
A
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
C579
Q
F
Q
D
D
R
H
C
S
R
L
R
T
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
N475
L
K
E
P
V
P
G
N
G
K
H
A
C
S
A
Honey Bee
Apis mellifera
XP_392346
1120
127429
P405
T
L
L
A
H
Y
P
P
V
H
V
V
Y
E
R
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
K471
P
V
E
H
L
L
P
K
K
Q
F
M
T
A
E
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
C552
K
V
V
K
R
E
I
C
R
I
S
T
Q
A
T
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
L561
G
P
L
N
K
T
D
L
D
T
T
N
L
N
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
S553
D
Q
D
C
S
A
L
S
C
L
L
S
E
M
R
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
N527
V
K
F
N
S
A
P
N
A
I
F
N
E
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
20
N.A.
100
93.3
N.A.
N.A.
100
93.3
6.6
N.A.
6.6
0
0
20
P-Site Similarity:
100
N.A.
100
26.6
N.A.
100
93.3
N.A.
N.A.
100
93.3
13.3
N.A.
20
6.6
13.3
20
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
20
7
0
7
0
0
7
0
14
47
% A
% Cys:
0
0
0
7
0
0
40
14
7
0
0
0
7
0
0
% C
% Asp:
7
0
47
47
14
0
7
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
14
0
0
7
0
0
0
0
0
0
14
7
14
% E
% Phe:
40
7
14
0
0
0
0
0
0
34
14
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% G
% His:
0
0
0
7
7
40
7
0
0
7
7
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
14
0
0
0
0
0
% I
% Lys:
7
14
0
7
7
0
0
14
7
7
0
0
0
0
7
% K
% Leu:
7
7
14
0
7
7
7
7
0
20
14
0
54
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% M
% Asn:
0
0
0
14
0
0
0
14
0
0
0
14
0
7
0
% N
% Pro:
7
7
0
7
0
7
20
7
0
0
0
0
0
0
0
% P
% Gln:
7
14
7
0
0
0
0
0
0
7
0
0
7
0
0
% Q
% Arg:
0
0
0
0
47
7
0
0
47
7
47
7
0
0
14
% R
% Ser:
7
34
0
0
14
0
0
47
7
0
7
7
0
7
0
% S
% Thr:
7
0
0
0
0
7
0
0
7
7
7
54
14
0
7
% T
% Val:
7
14
7
0
7
0
0
0
7
0
7
7
0
47
14
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _