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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH6 All Species: 32.42
Human Site: S830 Identified Species: 50.95
UniProt: P52701 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52701 NP_000170.1 1360 152786 S830 S K I H N V G S P L K S Q N H
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113749 1360 152750 S830 S K I H N V G S P L K S Q N H
Dog Lupus familis XP_531814 1283 145094 E799 K I I E I M E E V V D N F K S
Cat Felis silvestris
Mouse Mus musculus P54276 1358 151058 S827 S K I H N V G S P L K S Q N H
Rat Rattus norvegicus XP_002726765 1361 151628 S830 S K I H N V G S P L K S Q N H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419359 1466 164165 S936 S K I H S I G S P L K S Q N H
Frog Xenopus laevis NP_001089247 1340 149481 S810 S K I H S I G S P L K S Q N H
Zebra Danio Brachydanio rerio NP_878280 1369 153213 T831 S K I H S M G T P L K G Q D H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUM0 1190 133117 T714 N D L T K L P T M F H Q C K T
Honey Bee Apis mellifera XP_392346 1120 127429 R644 G Q T Y S K K R I T D F I T T
Nematode Worm Caenorhab. elegans NP_491163 1186 133609 L710 G F K L C N K L R K E Y I K V
Sea Urchin Strong. purpuratus XP_797647 1335 149141 S802 S K I H T L G S S K R N S D H
Poplar Tree Populus trichocarpa XP_002320307 1288 142120 K804 P D I L P I L K H F K S A F D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04716 1324 146779 S792 L I A R M F S S I E A S G R N
Baker's Yeast Sacchar. cerevisiae Q03834 1242 140062 R766 S W T N A F E R Q K A I N E N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.3 88.1 N.A. 85.8 86.4 N.A. N.A. 64.2 66.5 60 N.A. 39 41.2 34.4 48.6
Protein Similarity: 100 N.A. 98.6 91.3 N.A. 92.1 92.8 N.A. N.A. 75.4 79.9 74.9 N.A. 57.6 58 52.7 66.6
P-Site Identity: 100 N.A. 100 6.6 N.A. 100 100 N.A. N.A. 86.6 86.6 66.6 N.A. 0 0 0 46.6
P-Site Similarity: 100 N.A. 100 26.6 N.A. 100 100 N.A. N.A. 100 100 93.3 N.A. 26.6 20 6.6 73.3
Percent
Protein Identity: 36.1 N.A. N.A. 33.2 29 N.A.
Protein Similarity: 52 N.A. N.A. 51.4 49.1 N.A.
P-Site Identity: 20 N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 0 0 0 0 14 0 7 0 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 14 0 0 0 0 0 0 0 0 14 0 0 14 7 % D
% Glu: 0 0 0 7 0 0 14 7 0 7 7 0 0 7 0 % E
% Phe: 0 7 0 0 0 14 0 0 0 14 0 7 7 7 0 % F
% Gly: 14 0 0 0 0 0 54 0 0 0 0 7 7 0 0 % G
% His: 0 0 0 54 0 0 0 0 7 0 7 0 0 0 54 % H
% Ile: 0 14 67 0 7 20 0 0 14 0 0 7 14 0 0 % I
% Lys: 7 54 7 0 7 7 14 7 0 20 54 0 0 20 0 % K
% Leu: 7 0 7 14 0 14 7 7 0 47 0 0 0 0 0 % L
% Met: 0 0 0 0 7 14 0 0 7 0 0 0 0 0 0 % M
% Asn: 7 0 0 7 27 7 0 0 0 0 0 14 7 40 14 % N
% Pro: 7 0 0 0 7 0 7 0 47 0 0 0 0 0 0 % P
% Gln: 0 7 0 0 0 0 0 0 7 0 0 7 47 0 0 % Q
% Arg: 0 0 0 7 0 0 0 14 7 0 7 0 0 7 0 % R
% Ser: 60 0 0 0 27 0 7 54 7 0 0 54 7 0 7 % S
% Thr: 0 0 14 7 7 0 0 14 0 7 0 0 0 7 14 % T
% Val: 0 0 0 0 0 27 0 0 7 7 0 0 0 0 7 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _