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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
28.79
Human Site:
T924
Identified Species:
45.24
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
T924
D
H
E
K
A
R
K
T
G
L
I
T
P
K
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
T924
D
H
E
K
A
R
K
T
G
L
I
T
P
K
A
Dog
Lupus familis
XP_531814
1283
145094
G885
E
K
Q
R
S
R
I
G
C
R
T
I
V
Y
W
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
T921
D
H
E
K
A
R
K
T
G
L
I
T
P
K
A
Rat
Rattus norvegicus
XP_002726765
1361
151628
T924
D
H
E
K
A
R
K
T
G
L
I
T
P
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
T1030
D
H
N
Q
A
R
K
T
G
V
I
T
P
K
A
Frog
Xenopus laevis
NP_001089247
1340
149481
T904
D
H
E
K
A
R
K
T
G
V
I
T
P
K
A
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
T925
D
H
Q
K
A
R
T
T
G
V
I
T
P
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
C799
E
Q
E
R
H
F
G
C
R
I
T
Y
F
G
S
Honey Bee
Apis mellifera
XP_392346
1120
127429
E729
S
V
L
M
E
L
E
E
I
K
K
D
S
E
Q
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
K795
D
Y
K
D
S
V
A
K
K
Y
S
C
S
I
K
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
K896
D
Q
K
K
A
K
E
K
G
A
I
I
P
C
K
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
L889
S
I
P
Q
D
Y
E
L
R
S
S
K
K
I
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
S878
D
W
V
E
A
H
N
S
G
R
V
I
P
H
E
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
K851
M
A
A
N
K
T
Y
K
R
Y
Y
S
D
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
100
100
N.A.
N.A.
80
93.3
80
N.A.
6.6
0
6.6
40
P-Site Similarity:
100
N.A.
100
33.3
N.A.
100
100
N.A.
N.A.
93.3
100
93.3
N.A.
33.3
13.3
26.6
60
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
26.6
0
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
46.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
60
0
7
0
0
7
0
0
0
0
47
% A
% Cys:
0
0
0
0
0
0
0
7
7
0
0
7
0
7
0
% C
% Asp:
67
0
0
7
7
0
0
0
0
0
0
7
7
0
0
% D
% Glu:
14
0
40
7
7
0
20
7
0
0
0
0
0
14
7
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
7
7
60
0
0
0
0
7
7
% G
% His:
0
47
0
0
7
7
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
7
0
0
0
0
7
0
7
7
54
20
0
14
0
% I
% Lys:
0
7
14
47
7
7
40
20
7
7
7
7
7
47
14
% K
% Leu:
0
0
7
0
0
7
0
7
0
27
0
0
0
0
0
% L
% Met:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
0
0
60
0
0
% P
% Gln:
0
14
14
14
0
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
14
0
54
0
0
20
14
0
0
0
0
0
% R
% Ser:
14
0
0
0
14
0
0
7
0
7
14
7
14
0
7
% S
% Thr:
0
0
0
0
0
7
7
47
0
0
14
47
0
0
0
% T
% Val:
0
7
7
0
0
7
0
0
0
20
7
0
7
0
7
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
7
0
0
0
7
7
0
0
14
7
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _