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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
10
Human Site:
Y709
Identified Species:
15.71
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y709
S
M
A
N
F
E
E
Y
I
P
L
D
S
D
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y709
S
M
A
N
F
E
E
Y
I
P
L
D
S
D
I
Dog
Lupus familis
XP_531814
1283
145094
K683
T
E
G
T
L
L
E
K
I
D
T
C
H
T
P
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
P708
A
N
F
E
E
Y
F
P
L
D
S
D
T
V
S
Rat
Rattus norvegicus
XP_002726765
1361
151628
P711
A
N
F
E
E
Y
F
P
L
D
S
D
M
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y815
S
L
A
N
F
E
K
Y
I
P
V
D
A
D
N
Frog
Xenopus laevis
NP_001089247
1340
149481
E688
L
S
M
A
N
F
E
E
Y
V
P
V
D
T
D
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
E708
L
F
S
M
G
N
F
E
E
Y
V
P
V
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
H604
S
L
L
S
T
L
D
H
C
C
T
K
F
G
K
Honey Bee
Apis mellifera
XP_392346
1120
127429
A534
N
K
T
F
V
L
D
A
I
T
I
N
N
L
R
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
N600
T
S
L
Y
Y
V
I
N
K
C
S
T
P
F
G
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Y681
K
A
L
M
E
K
G
Y
F
E
D
S
E
R
D
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
S690
R
P
L
Y
H
L
E
S
I
K
D
R
Q
D
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
L682
R
F
A
K
F
E
S
L
P
Y
C
D
F
S
N
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
K656
P
M
G
K
R
M
M
K
K
W
L
M
H
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
13.3
N.A.
6.6
6.6
N.A.
N.A.
66.6
6.6
6.6
N.A.
6.6
6.6
0
6.6
P-Site Similarity:
100
N.A.
93.3
20
N.A.
33.3
20
N.A.
N.A.
93.3
6.6
20
N.A.
33.3
40
13.3
13.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
20
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
27
7
0
0
0
7
0
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
14
7
7
0
0
0
% C
% Asp:
0
0
0
0
0
0
14
0
0
20
14
40
7
34
14
% D
% Glu:
0
7
0
14
20
27
34
14
7
7
0
0
7
0
0
% E
% Phe:
0
14
14
7
27
7
20
0
7
0
0
0
14
7
0
% F
% Gly:
0
0
14
0
7
0
7
0
0
0
0
0
0
7
14
% G
% His:
0
0
0
0
7
0
0
7
0
0
0
0
14
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
40
0
7
0
0
0
7
% I
% Lys:
7
7
0
14
0
7
7
14
14
7
0
7
0
0
7
% K
% Leu:
14
14
27
0
7
27
0
7
14
0
20
0
0
7
7
% L
% Met:
0
20
7
14
0
7
7
0
0
0
0
7
7
0
0
% M
% Asn:
7
14
0
20
7
7
0
7
0
0
0
7
7
0
14
% N
% Pro:
7
7
0
0
0
0
0
14
7
20
7
7
7
7
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
14
0
0
0
7
0
0
0
0
0
0
7
0
7
7
% R
% Ser:
27
14
7
7
0
0
7
7
0
0
20
7
14
7
7
% S
% Thr:
14
0
7
7
7
0
0
0
0
7
14
7
7
14
7
% T
% Val:
0
0
0
0
7
7
0
0
0
7
14
7
7
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
14
7
14
0
27
7
14
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _