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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMS All Species: 9.7
Human Site: T21 Identified Species: 19.39
UniProt: P52788 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52788 NP_004586.2 366 41268 T21 G A K A D G E T I L K G L Q S
Chimpanzee Pan troglodytes XP_001142843 367 41364 T21 G A K A D G E T I L K G L Q S
Rhesus Macaque Macaca mulatta XP_001086702 408 45991 T43 G A K A D G E T I L K G L Q S
Dog Lupus familis XP_537978 270 30555
Cat Felis silvestris
Mouse Mus musculus P97355 366 41295 A21 G A K A D G E A I L K G L Q S
Rat Rattus norvegicus XP_001062228 366 41276 A21 G A K A D G E A I L K G L Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513704 522 59135 V176 G A S T D G S V I V K G L Q S
Chicken Gallus gallus NP_001025974 367 41879 A21 G A T A D C N A V L K A L Q P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_571831 360 40601 T21 A P A D V S A T V R G L Q S I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_729798 367 42477 K28 E A R L Q V A K I L R N E L E
Honey Bee Apis mellifera XP_393567 366 41561 K27 V E K R S T L K L A I T N V L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789223 457 51774 E29 Q T G S K I N E Q L K G A L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 86.5 73.2 N.A. 96.1 96.9 N.A. 59.3 86.6 N.A. 69.6 N.A. 43 42.6 N.A. 39.8
Protein Similarity: 100 99.7 87.7 73.7 N.A. 98 98.6 N.A. 64.5 92.3 N.A. 84.4 N.A. 62.1 62.5 N.A. 55.5
P-Site Identity: 100 100 100 0 N.A. 93.3 93.3 N.A. 66.6 53.3 N.A. 6.6 N.A. 20 6.6 N.A. 26.6
P-Site Similarity: 100 100 100 0 N.A. 93.3 93.3 N.A. 73.3 60 N.A. 13.3 N.A. 33.3 13.3 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 67 9 50 0 0 17 25 0 9 0 9 9 0 0 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 59 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 9 0 0 0 0 42 9 0 0 0 0 9 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 59 0 9 0 0 50 0 0 0 0 9 59 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 59 0 9 0 0 0 9 % I
% Lys: 0 0 50 0 9 0 0 17 0 0 67 0 0 0 0 % K
% Leu: 0 0 0 9 0 0 9 0 9 67 0 9 59 17 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 17 0 0 0 0 9 9 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 9 % P
% Gln: 9 0 0 0 9 0 0 0 9 0 0 0 9 59 0 % Q
% Arg: 0 0 9 9 0 0 0 0 0 9 9 0 0 0 0 % R
% Ser: 0 0 9 9 9 9 9 0 0 0 0 0 0 9 59 % S
% Thr: 0 9 9 9 0 9 0 34 0 0 0 9 0 0 0 % T
% Val: 9 0 0 0 9 9 0 9 17 9 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _