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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKQ All Species: 3.64
Human Site: S280 Identified Species: 6.15
UniProt: P52824 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52824 NP_001338.2 942 101155 S280 G G D G A D G S A A V G P G R
Chimpanzee Pan troglodytes XP_517054 558 59289
Rhesus Macaque Macaca mulatta XP_001085047 955 102930 F285 L H P D C V P F A C S D C R Q
Dog Lupus familis XP_545985 883 96080 V226 P G D E D D G V D G S T P A G
Cat Felis silvestris
Mouse Mus musculus Q6P5E8 934 102236 S276 G D D G V D G S A A I G T G R
Rat Rattus norvegicus P49620 788 88503 P173 S L M E T G R P Q D K L E F M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514085 793 88823 N179 T I P R I A Q N E E V L E A A
Chicken Gallus gallus XP_424953 1170 127536 G527 D E G D D V D G S T Q G P A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q09103 1457 160124 G399 S A D A D D A G A A M G L P V
Honey Bee Apis mellifera XP_623068 890 99825 I220 T E V P M E A I I G V Q V R R
Nematode Worm Caenorhab. elegans Q03603 812 91362 I198 D K S E I D G I I E Q M M N V
Sea Urchin Strong. purpuratus XP_001203750 808 90577 D194 D I V S R I Q D F I G S S A Q
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001169174 697 77246 G83 S E D Y F H G G Q P S T C C V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 F114 A I V A S E S F F H R C T I C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.2 68.6 74.9 N.A. 80.6 24.3 N.A. 56.5 54.8 N.A. N.A. N.A. 20.1 40.8 25.6 34.9
Protein Similarity: 100 51.5 72.1 81.5 N.A. 86.4 39.9 N.A. 68.3 65.3 N.A. N.A. N.A. 32.7 58.8 41.5 52.6
P-Site Identity: 100 0 6.6 33.3 N.A. 73.3 0 N.A. 6.6 13.3 N.A. N.A. N.A. 33.3 13.3 13.3 0
P-Site Similarity: 100 0 13.3 33.3 N.A. 80 0 N.A. 13.3 26.6 N.A. N.A. N.A. 40 20 13.3 6.6
Percent
Protein Identity: N.A. 28.6 N.A. 25.4 N.A. N.A.
Protein Similarity: N.A. 41.7 N.A. 39.9 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 15 8 8 15 0 29 22 0 0 0 29 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 8 0 8 15 8 8 % C
% Asp: 22 8 36 15 22 36 8 8 8 8 0 8 0 0 0 % D
% Glu: 0 22 0 22 0 15 0 0 8 15 0 0 15 0 0 % E
% Phe: 0 0 0 0 8 0 0 15 15 0 0 0 0 8 0 % F
% Gly: 15 15 8 15 0 8 36 22 0 15 8 29 0 15 8 % G
% His: 0 8 0 0 0 8 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 22 0 0 15 8 0 15 15 8 8 0 0 8 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 8 % K
% Leu: 8 8 0 0 0 0 0 0 0 0 0 15 8 0 0 % L
% Met: 0 0 8 0 8 0 0 0 0 0 8 8 8 0 8 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 0 0 8 0 % N
% Pro: 8 0 15 8 0 0 8 8 0 8 0 0 22 8 0 % P
% Gln: 0 0 0 0 0 0 15 0 15 0 15 8 0 0 15 % Q
% Arg: 0 0 0 8 8 0 8 0 0 0 8 0 0 15 22 % R
% Ser: 22 0 8 8 8 0 8 15 8 0 22 8 8 0 0 % S
% Thr: 15 0 0 0 8 0 0 0 0 8 0 15 15 0 0 % T
% Val: 0 0 22 0 8 15 0 8 0 0 22 0 8 0 22 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _