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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKQ All Species: 5.45
Human Site: S353 Identified Species: 9.23
UniProt: P52824 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52824 NP_001338.2 942 101155 S353 E L C R L P P S S Q A C D A W
Chimpanzee Pan troglodytes XP_517054 558 59289
Rhesus Macaque Macaca mulatta XP_001085047 955 102930 S367 E L C P L P P S L K A C D T W
Dog Lupus familis XP_545985 883 96080 Q294 D P R D F E L Q P V P A P V P
Cat Felis silvestris
Mouse Mus musculus Q6P5E8 934 102236 L346 K D F Q L Q A L P L S G N A Q
Rat Rattus norvegicus P49620 788 88503 G228 I L K E M L Q G M D Y N K D G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514085 793 88823 A234 G S V F K E S A P E A W I I R
Chicken Gallus gallus XP_424953 1170 127536 F597 Q E Y E L Q T F T Q Q A L L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q09103 1457 160124 S518 K T E E L Q P S A D G C F L T
Honey Bee Apis mellifera XP_623068 890 99825 N284 H I T K D P S N F Y L T D V Y
Nematode Worm Caenorhab. elegans Q03603 812 91362 L253 T N I P L L V L L G F D T E M
Sea Urchin Strong. purpuratus XP_001203750 808 90577 L249 K D T T M K Q L T E T A M R S
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001169174 697 77246 L138 Q A G A S P L L H H W S E R W
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 C169 Q T D D S S F C S Y C D E S C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.2 68.6 74.9 N.A. 80.6 24.3 N.A. 56.5 54.8 N.A. N.A. N.A. 20.1 40.8 25.6 34.9
Protein Similarity: 100 51.5 72.1 81.5 N.A. 86.4 39.9 N.A. 68.3 65.3 N.A. N.A. N.A. 32.7 58.8 41.5 52.6
P-Site Identity: 100 0 73.3 0 N.A. 13.3 6.6 N.A. 6.6 13.3 N.A. N.A. N.A. 26.6 13.3 6.6 0
P-Site Similarity: 100 0 80 6.6 N.A. 40 13.3 N.A. 20 26.6 N.A. N.A. N.A. 40 40 6.6 26.6
Percent
Protein Identity: N.A. 28.6 N.A. 25.4 N.A. N.A.
Protein Similarity: N.A. 41.7 N.A. 39.9 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. 26.6 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 0 8 8 8 0 22 22 0 15 0 % A
% Cys: 0 0 15 0 0 0 0 8 0 0 8 22 0 0 8 % C
% Asp: 8 15 8 15 8 0 0 0 0 15 0 15 22 8 0 % D
% Glu: 15 8 8 22 0 15 0 0 0 15 0 0 15 8 0 % E
% Phe: 0 0 8 8 8 0 8 8 8 0 8 0 8 0 0 % F
% Gly: 8 0 8 0 0 0 0 8 0 8 8 8 0 0 8 % G
% His: 8 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % H
% Ile: 8 8 8 0 0 0 0 0 0 0 0 0 8 8 0 % I
% Lys: 22 0 8 8 8 8 0 0 0 8 0 0 8 0 0 % K
% Leu: 0 22 0 0 43 15 15 29 15 8 8 0 8 15 0 % L
% Met: 0 0 0 0 15 0 0 0 8 0 0 0 8 0 8 % M
% Asn: 0 8 0 0 0 0 0 8 0 0 0 8 8 0 0 % N
% Pro: 0 8 0 15 0 29 22 0 22 0 8 0 8 0 8 % P
% Gln: 22 0 0 8 0 22 15 8 0 15 8 0 0 0 8 % Q
% Arg: 0 0 8 8 0 0 0 0 0 0 0 0 0 15 8 % R
% Ser: 0 8 0 0 15 8 15 22 15 0 8 8 0 8 15 % S
% Thr: 8 15 15 8 0 0 8 0 15 0 8 8 8 8 8 % T
% Val: 0 0 8 0 0 0 8 0 0 8 0 0 0 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 22 % W
% Tyr: 0 0 8 0 0 0 0 0 0 15 8 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _