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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-5
All Species:
13.03
Human Site:
S311
Identified Species:
26.06
UniProt:
P52952
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52952
NP_004378.1
324
34918
S311
Q
S
P
G
I
P
Q
S
N
S
G
V
S
T
L
Chimpanzee
Pan troglodytes
XP_518104
325
35024
S312
Q
S
P
G
I
P
Q
S
N
S
G
V
S
T
L
Rhesus Macaque
Macaca mulatta
XP_001096796
324
34944
S311
Q
S
P
G
I
P
Q
S
N
S
G
V
S
T
L
Dog
Lupus familis
XP_543239
342
36276
Q329
G
G
P
G
G
T
S
Q
G
P
V
A
A
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P42582
318
34144
G305
Q
S
P
G
M
P
Q
G
N
S
G
V
S
T
L
Rat
Rattus norvegicus
O35767
318
34318
G305
Q
S
P
G
M
P
Q
G
N
S
G
V
S
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
N282
Q
P
P
I
P
Q
G
N
A
G
I
S
T
L
H
Frog
Xenopus laevis
P42583
299
34079
S287
Q
T
P
I
Q
Q
A
S
S
V
S
A
L
H
H
Zebra Danio
Brachydanio rerio
Q90481
269
30288
T257
A
T
T
P
Q
F
P
T
A
H
H
L
V
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
Q445
L
A
M
A
Y
R
N
Q
N
N
F
I
S
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
A287
A
A
F
N
F
P
F
A
A
Q
G
P
N
P
A
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
S320
Q
A
T
S
F
S
N
S
C
N
Y
E
Y
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
40
N.A.
87.6
85.8
N.A.
N.A.
66.6
62.3
32.4
N.A.
26.9
N.A.
29.3
35.1
Protein Similarity:
100
99.3
97.8
49.7
N.A.
91.3
89.5
N.A.
N.A.
76.8
73.7
43.8
N.A.
40.5
N.A.
42.2
49.7
P-Site Identity:
100
100
100
20
N.A.
86.6
86.6
N.A.
N.A.
13.3
20
0
N.A.
13.3
N.A.
13.3
20
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
93.3
N.A.
N.A.
26.6
33.3
20
N.A.
33.3
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
25
0
9
0
0
9
9
25
0
0
17
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
9
0
17
9
9
0
0
0
9
0
0
0
0
% F
% Gly:
9
9
0
50
9
0
9
17
9
9
50
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
9
9
0
0
9
17
% H
% Ile:
0
0
0
17
25
0
0
0
0
0
9
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
0
0
0
0
0
0
0
0
9
9
9
50
% L
% Met:
0
0
9
0
17
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
17
9
50
17
0
0
9
9
0
% N
% Pro:
0
9
67
9
9
50
9
0
0
9
0
9
0
9
0
% P
% Gln:
67
0
0
0
17
17
42
17
0
9
0
0
0
9
0
% Q
% Arg:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
42
0
9
0
9
9
42
9
42
9
9
50
0
0
% S
% Thr:
0
17
17
0
0
9
0
9
0
0
0
0
9
50
17
% T
% Val:
0
0
0
0
0
0
0
0
0
9
9
42
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
9
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _