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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-5
All Species:
14.55
Human Site:
Y259
Identified Species:
29.09
UniProt:
P52952
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52952
NP_004378.1
324
34918
Y259
A
Y
P
A
Y
P
G
Y
G
G
A
A
C
S
P
Chimpanzee
Pan troglodytes
XP_518104
325
35024
Y260
A
Y
P
A
Y
P
G
Y
G
G
A
A
C
S
P
Rhesus Macaque
Macaca mulatta
XP_001096796
324
34944
Y259
A
Y
P
A
Y
P
C
Y
G
G
A
A
C
S
P
Dog
Lupus familis
XP_543239
342
36276
Y282
Y
G
A
P
A
A
P
Y
S
C
Y
G
G
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
P42582
318
34144
G255
A
Y
P
Y
P
S
Y
G
G
A
A
C
S
P
G
Rat
Rattus norvegicus
O35767
318
34318
G255
A
Y
P
Y
P
G
Y
G
G
A
A
C
S
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
Y235
A
Y
P
A
Y
P
N
Y
N
S
P
A
C
N
A
Frog
Xenopus laevis
P42583
299
34079
Y240
T
Y
P
A
Y
S
N
Y
S
N
P
A
C
S
G
Zebra Danio
Brachydanio rerio
Q90481
269
30288
K210
P
V
L
V
R
D
G
K
P
C
H
T
L
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
N375
T
G
S
A
N
N
G
N
A
N
S
G
I
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
P228
E
D
G
S
S
P
P
P
D
N
D
D
D
D
D
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
R263
A
A
A
A
A
A
A
R
H
Q
Q
N
N
D
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
40
N.A.
87.6
85.8
N.A.
N.A.
66.6
62.3
32.4
N.A.
26.9
N.A.
29.3
35.1
Protein Similarity:
100
99.3
97.8
49.7
N.A.
91.3
89.5
N.A.
N.A.
76.8
73.7
43.8
N.A.
40.5
N.A.
42.2
49.7
P-Site Identity:
100
100
93.3
6.6
N.A.
33.3
33.3
N.A.
N.A.
60
53.3
6.6
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
93.3
6.6
N.A.
33.3
33.3
N.A.
N.A.
66.6
53.3
6.6
N.A.
20
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
9
17
59
17
17
9
0
9
17
42
42
0
0
34
% A
% Cys:
0
0
0
0
0
0
9
0
0
17
0
17
42
0
0
% C
% Asp:
0
9
0
0
0
9
0
0
9
0
9
9
9
17
9
% D
% Glu:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
17
9
0
0
9
34
17
42
25
0
17
9
0
17
% G
% His:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
9
0
0
0
0
0
9
0
% K
% Leu:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
9
17
9
9
25
0
9
9
9
0
% N
% Pro:
9
0
59
9
17
42
17
9
9
0
17
0
0
17
25
% P
% Gln:
0
0
0
0
0
0
0
0
0
9
9
0
0
0
9
% Q
% Arg:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
9
9
17
0
0
17
9
9
0
17
34
9
% S
% Thr:
17
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% T
% Val:
0
9
0
9
0
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
59
0
17
42
0
17
50
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _