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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-5
All Species:
12.42
Human Site:
Y274
Identified Species:
24.85
UniProt:
P52952
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52952
NP_004378.1
324
34918
Y274
G
Y
S
C
T
A
A
Y
P
A
G
P
S
P
A
Chimpanzee
Pan troglodytes
XP_518104
325
35024
Y275
G
Y
S
C
T
A
A
Y
P
A
G
P
S
P
A
Rhesus Macaque
Macaca mulatta
XP_001096796
324
34944
Y274
G
Y
S
C
T
A
A
Y
P
T
G
P
S
P
A
Dog
Lupus familis
XP_543239
342
36276
Y297
G
A
P
F
G
A
G
Y
G
G
G
Y
A
S
A
Cat
Felis silvestris
Mouse
Mus musculus
P42582
318
34144
A270
Y
S
C
A
A
Y
P
A
A
P
P
A
A
Q
P
Rat
Rattus norvegicus
O35767
318
34318
A270
Y
S
C
A
A
Y
P
A
A
P
P
A
A
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
A250
N
Y
N
C
S
Y
P
A
V
Q
P
V
Q
P
S
Frog
Xenopus laevis
P42583
299
34079
S255
S
Y
N
C
S
Y
S
S
M
P
S
M
Q
P
T
Zebra Danio
Brachydanio rerio
Q90481
269
30288
Q225
Q
D
L
A
A
T
F
Q
A
G
I
P
F
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
G390
V
T
A
N
V
S
G
G
L
N
L
I
T
G
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
D243
K
Y
S
I
E
M
D
D
K
D
D
E
E
E
E
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
V278
Y
S
A
R
R
V
A
V
P
V
L
V
R
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
40
N.A.
87.6
85.8
N.A.
N.A.
66.6
62.3
32.4
N.A.
26.9
N.A.
29.3
35.1
Protein Similarity:
100
99.3
97.8
49.7
N.A.
91.3
89.5
N.A.
N.A.
76.8
73.7
43.8
N.A.
40.5
N.A.
42.2
49.7
P-Site Identity:
100
100
93.3
33.3
N.A.
0
6.6
N.A.
N.A.
20
20
13.3
N.A.
0
N.A.
13.3
13.3
P-Site Similarity:
100
100
93.3
40
N.A.
6.6
13.3
N.A.
N.A.
40
40
13.3
N.A.
20
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
17
25
25
34
34
25
25
17
0
17
25
0
50
% A
% Cys:
0
0
17
42
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
9
9
0
9
9
0
0
9
9
% D
% Glu:
0
0
0
0
9
0
0
0
0
0
0
9
9
9
9
% E
% Phe:
0
0
0
9
0
0
9
0
0
0
0
0
9
0
0
% F
% Gly:
34
0
0
0
9
0
17
9
9
17
34
0
0
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
0
9
0
0
0
0
0
0
9
9
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
0
9
0
17
0
0
0
0
% L
% Met:
0
0
0
0
0
9
0
0
9
0
0
9
0
0
0
% M
% Asn:
9
0
17
9
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
25
0
34
25
25
34
0
42
9
% P
% Gln:
9
0
0
0
0
0
0
9
0
9
0
0
17
9
0
% Q
% Arg:
0
0
0
9
9
0
0
0
0
0
0
0
9
0
0
% R
% Ser:
9
25
34
0
17
9
9
9
0
0
9
0
25
17
9
% S
% Thr:
0
9
0
0
25
9
0
0
0
9
0
0
9
0
9
% T
% Val:
9
0
0
0
9
9
0
9
9
9
0
17
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
25
50
0
0
0
34
0
34
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _