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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX2-5 All Species: 11.21
Human Site: Y56 Identified Species: 22.42
UniProt: P52952 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52952 NP_004378.1 324 34918 Y56 A A F K P E A Y A G P E A A A
Chimpanzee Pan troglodytes XP_518104 325 35024 Y56 A A F K P E A Y A G P E A A A
Rhesus Macaque Macaca mulatta XP_001096796 324 34944 Y56 A T F K P E A Y A G P E A A A
Dog Lupus familis XP_543239 342 36276 G64 P P W R T L S G I S Q E L P A
Cat Felis silvestris
Mouse Mus musculus P42582 318 34144 S56 A F K P E A Y S G P E A A A S
Rat Rattus norvegicus O35767 318 34318 S56 A F K P D G Y S G P E A A A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90788 294 33054 E56 S E P P A L P E L P E P P P A
Frog Xenopus laevis P42583 299 34079 L56 S Y P G T P C L S E L T E E M
Zebra Danio Brachydanio rerio Q90481 269 30288 S50 T P G V L V Q S P L E N V Q N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015473 468 50968 L122 P F S V T D I L S P I E E S Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9NLC2 299 33058 L58 I L S P L E S L V R V Q Q Q L
Sea Urchin Strong. purpuratus XP_783123 344 37966 S70 C M L P D P G S M P P P C D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.8 40 N.A. 87.6 85.8 N.A. N.A. 66.6 62.3 32.4 N.A. 26.9 N.A. 29.3 35.1
Protein Similarity: 100 99.3 97.8 49.7 N.A. 91.3 89.5 N.A. N.A. 76.8 73.7 43.8 N.A. 40.5 N.A. 42.2 49.7
P-Site Identity: 100 100 93.3 13.3 N.A. 20 20 N.A. N.A. 6.6 0 0 N.A. 6.6 N.A. 6.6 6.6
P-Site Similarity: 100 100 93.3 33.3 N.A. 26.6 20 N.A. N.A. 13.3 13.3 0 N.A. 26.6 N.A. 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 42 17 0 0 9 9 25 0 25 0 0 17 42 42 42 % A
% Cys: 9 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % C
% Asp: 0 0 0 0 17 9 0 0 0 0 0 0 0 9 0 % D
% Glu: 0 9 0 0 9 34 0 9 0 9 34 42 17 9 0 % E
% Phe: 0 25 25 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 9 0 9 9 9 17 25 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 9 0 9 0 9 0 0 0 0 % I
% Lys: 0 0 17 25 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 9 0 17 17 0 25 9 9 9 0 9 0 9 % L
% Met: 0 9 0 0 0 0 0 0 9 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 9 % N
% Pro: 17 17 17 42 25 17 9 0 9 42 34 17 9 17 9 % P
% Gln: 0 0 0 0 0 0 9 0 0 0 9 9 9 17 0 % Q
% Arg: 0 0 0 9 0 0 0 0 0 9 0 0 0 0 0 % R
% Ser: 17 0 17 0 0 0 17 34 17 9 0 0 0 9 9 % S
% Thr: 9 9 0 0 25 0 0 0 0 0 0 9 0 0 0 % T
% Val: 0 0 0 17 0 9 0 0 9 0 9 0 9 0 0 % V
% Trp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 17 25 0 0 0 0 0 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _