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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP5C All Species: 26.06
Human Site: T75 Identified Species: 35.83
UniProt: P53041 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53041 NP_006238.1 499 56879 T75 R S L A Y L R T E C Y G Y A L
Chimpanzee Pan troglodytes XP_512768 499 56846 T75 R S L A Y L R T E C Y G Y A L
Rhesus Macaque Macaca mulatta XP_001111749 499 56900 T75 R S L A Y L R T E C Y G Y A L
Dog Lupus familis XP_855029 473 53972 K68 R A I E I D K K Y I K G Y Y R
Cat Felis silvestris
Mouse Mus musculus Q60676 499 56828 T75 R S L A Y L R T E C Y G Y A L
Rat Rattus norvegicus P53042 499 56898 T75 R S L A Y L R T E C Y G Y A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P48463 309 35545
Frog Xenopus laevis Q6IP91 307 35104
Zebra Danio Brachydanio rerio A9JRC7 307 35078
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23696 309 35450
Honey Bee Apis mellifera XP_624242 489 56031 T66 R S F A Y L K T E F F G Y A L
Nematode Worm Caenorhab. elegans Q9XW79 333 37341
Sea Urchin Strong. purpuratus XP_796785 500 56974 T78 R S F A Y L K T E C F G S A L
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001150042 483 54661 V66 L E E Y G S A V Q D A T K A I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84XU2 538 60264 M94 R G A A Y L A M G K F K D A L
Baker's Yeast Sacchar. cerevisiae P53043 513 57976 R86 N I K A Y H R R A L S C M A L
Red Bread Mold Neurospora crassa Q9UW86 308 35549
Conservation
Percent
Protein Identity: 100 99.8 99.4 91.5 N.A. 98 98 N.A. N.A. 27.4 29 28.8 N.A. 26.8 63.7 30 64.6
Protein Similarity: 100 100 99.8 93.1 N.A. 99.1 99.4 N.A. N.A. 40.4 40.2 40 N.A. 39.6 79.9 43 81.6
P-Site Identity: 100 100 100 20 N.A. 100 100 N.A. N.A. 0 0 0 N.A. 0 73.3 0 73.3
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. N.A. 0 0 0 N.A. 0 86.6 0 86.6
Percent
Protein Identity: N.A. 55.1 N.A. 51.4 41.9 29.4
Protein Similarity: N.A. 73.1 N.A. 69.7 59.8 42.6
P-Site Identity: N.A. 6.6 N.A. 40 33.3 0
P-Site Similarity: N.A. 20 N.A. 46.6 33.3 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 53 0 0 12 0 6 0 6 0 0 59 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 36 0 6 0 0 0 % C
% Asp: 0 0 0 0 0 6 0 0 0 6 0 0 6 0 0 % D
% Glu: 0 6 6 6 0 0 0 0 42 0 0 0 0 0 0 % E
% Phe: 0 0 12 0 0 0 0 0 0 6 18 0 0 0 0 % F
% Gly: 0 6 0 0 6 0 0 0 6 0 0 48 0 0 0 % G
% His: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 6 6 0 6 0 0 0 0 6 0 0 0 0 6 % I
% Lys: 0 0 6 0 0 0 18 6 0 6 6 6 6 0 0 % K
% Leu: 6 0 30 0 0 48 0 0 0 6 0 0 0 0 53 % L
% Met: 0 0 0 0 0 0 0 6 0 0 0 0 6 0 0 % M
% Asn: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % Q
% Arg: 53 0 0 0 0 0 36 6 0 0 0 0 0 0 6 % R
% Ser: 0 42 0 0 0 6 0 0 0 0 6 0 6 0 0 % S
% Thr: 0 0 0 0 0 0 0 42 0 0 0 6 0 0 0 % T
% Val: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 6 53 0 0 0 6 0 30 0 42 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _