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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
39.09
Human Site:
S331
Identified Species:
53.75
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S331
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S331
R
F
S
I
A
P
S
S
L
D
P
S
T
R
K
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S331
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
Dog
Lupus familis
XP_547091
832
93293
S559
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S331
R
F
S
I
A
P
S
S
L
D
P
S
S
R
K
Rat
Rattus norvegicus
Q62673
603
68295
S331
R
F
S
I
A
P
S
S
L
D
P
S
N
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
P228
L
N
K
G
L
D
S
P
V
V
E
K
V
P
E
Chicken
Gallus gallus
NP_001025810
595
66904
T321
R
F
S
I
A
P
S
T
L
E
L
N
G
R
K
Frog
Xenopus laevis
P70032
598
68193
T322
R
F
S
I
A
P
S
T
I
D
Q
S
L
R
K
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
S317
R
F
S
I
A
P
S
S
L
D
P
A
L
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
I303
R
I
G
S
N
D
T
I
E
D
S
M
H
R
K
Honey Bee
Apis mellifera
XP_396707
575
66141
H301
R
L
D
M
L
E
M
H
N
Q
R
K
P
L
S
Nematode Worm
Caenorhab. elegans
P34331
649
73615
S316
K
F
G
G
H
E
T
S
M
M
E
E
N
V
A
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
S305
R
F
Q
V
P
V
S
S
G
R
R
P
L
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
Y314
A
C
P
P
S
T
S
Y
L
N
Q
F
A
S
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
I191
Y
N
G
A
V
A
D
I
W
S
C
G
V
I
L
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
I359
E
A
P
N
F
E
D
I
P
E
E
Q
S
L
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
93.3
100
100
N.A.
93.3
100
N.A.
6.6
66.6
73.3
73.3
N.A.
26.6
6.6
20
26.6
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
20
86.6
86.6
86.6
N.A.
40
13.3
40
40
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
0
6
53
6
0
0
0
0
0
6
6
0
6
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
6
0
0
0
0
% C
% Asp:
0
0
6
0
0
12
12
0
0
53
0
0
0
0
0
% D
% Glu:
6
0
0
0
0
18
0
0
6
12
18
6
0
0
12
% E
% Phe:
0
65
0
0
6
0
0
0
0
0
0
6
0
0
0
% F
% Gly:
0
0
18
12
0
0
0
0
6
0
0
6
6
0
0
% G
% His:
0
0
0
0
6
0
0
6
0
0
0
0
6
0
0
% H
% Ile:
0
6
0
53
0
0
0
18
6
0
0
0
0
6
0
% I
% Lys:
6
0
6
0
0
0
0
0
0
0
0
12
0
0
53
% K
% Leu:
6
6
0
0
12
0
0
0
53
0
6
0
18
24
6
% L
% Met:
0
0
0
6
0
0
6
0
6
6
0
6
0
0
0
% M
% Asn:
0
12
0
6
6
0
0
0
6
6
0
6
30
0
0
% N
% Pro:
0
0
12
6
6
53
0
6
6
0
42
6
6
6
6
% P
% Gln:
0
0
6
0
0
0
0
0
0
6
12
6
0
0
0
% Q
% Arg:
71
0
0
0
0
0
0
0
0
6
12
0
0
53
6
% R
% Ser:
0
0
53
6
6
0
71
53
0
6
6
42
12
6
6
% S
% Thr:
0
0
0
0
0
6
12
12
0
0
0
0
6
0
0
% T
% Val:
0
0
0
6
6
6
0
0
6
6
0
0
12
6
6
% V
% Trp:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% W
% Tyr:
6
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _