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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
27.88
Human Site:
S375
Identified Species:
38.33
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S375
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S375
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S375
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
Dog
Lupus familis
XP_547091
832
93293
R603
E
A
V
D
C
H
L
R
D
M
L
Q
Q
L
H
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S375
E
A
I
E
C
H
L
S
D
L
L
Q
Q
L
T
Rat
Rattus norvegicus
Q62673
603
68295
S375
E
A
I
E
C
H
L
S
D
L
L
Q
Q
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
V262
M
L
Q
Q
L
T
T
V
N
V
A
K
P
S
E
Chicken
Gallus gallus
NP_001025810
595
66904
A366
D
T
I
E
C
H
L
A
D
M
L
Q
Q
L
T
Frog
Xenopus laevis
P70032
598
68193
S369
E
P
A
D
C
Y
L
S
E
M
L
Q
Q
L
T
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
T366
E
Q
P
D
T
H
L
T
D
M
L
Q
Q
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
I338
K
A
N
L
H
D
A
I
T
A
S
A
Q
V
C
Honey Bee
Apis mellifera
XP_396707
575
66141
Q354
L
D
I
R
K
M
L
Q
T
L
R
E
Q
L
S
Nematode Worm
Caenorhab. elegans
P34331
649
73615
S376
E
P
E
D
A
Y
L
S
Q
L
F
H
Q
V
A
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
A356
Q
P
K
E
D
H
L
A
S
L
K
V
H
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
S355
R
F
I
N
T
Q
G
S
N
M
F
G
S
E
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
F225
S
K
I
D
K
A
E
F
S
C
P
S
Y
F
A
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
Q436
E
V
V
D
I
E
A
Q
R
R
L
N
D
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
86.6
N.A.
66.6
66.6
N.A.
0
60
66.6
66.6
N.A.
6.6
20
33.3
20
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
26.6
86.6
80
73.3
N.A.
20
40
53.3
46.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
40
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
6
0
6
6
12
12
0
6
6
6
0
0
24
% A
% Cys:
0
0
0
0
48
0
0
0
0
6
0
0
0
0
6
% C
% Asp:
6
6
0
53
6
6
0
0
48
0
0
0
6
0
0
% D
% Glu:
59
0
6
24
0
6
6
0
6
0
0
6
0
6
6
% E
% Phe:
0
6
0
0
0
0
0
6
0
0
12
0
0
6
0
% F
% Gly:
0
0
0
0
0
0
6
0
0
0
0
6
0
0
0
% G
% His:
0
0
0
0
6
53
0
0
0
0
0
6
6
0
24
% H
% Ile:
0
0
36
0
6
0
0
6
0
0
0
0
0
0
0
% I
% Lys:
6
6
6
0
12
0
0
0
0
0
6
6
0
0
6
% K
% Leu:
6
6
0
6
6
0
71
0
0
30
59
0
0
71
0
% L
% Met:
6
0
0
0
0
6
0
0
0
48
0
0
0
0
0
% M
% Asn:
0
0
6
6
0
0
0
0
12
0
0
6
0
0
0
% N
% Pro:
0
18
6
0
0
0
0
0
0
0
6
0
6
0
0
% P
% Gln:
6
6
6
6
0
6
0
12
6
0
0
53
71
0
0
% Q
% Arg:
6
0
0
6
0
0
0
6
6
6
6
0
0
0
0
% R
% Ser:
6
0
0
0
0
0
0
48
12
0
6
6
6
6
6
% S
% Thr:
0
6
0
0
12
6
6
6
12
0
0
0
0
0
30
% T
% Val:
0
24
30
0
0
0
0
6
0
6
0
6
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _