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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLK1 All Species: 27.88
Human Site: S375 Identified Species: 38.33
UniProt: P53350 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53350 NP_005021.2 603 68255 S375 E V V D C H L S D M L Q Q L H
Chimpanzee Pan troglodytes XP_001163623 603 68223 S375 E V V D C H L S D M L Q Q L H
Rhesus Macaque Macaca mulatta XP_001092070 603 68240 S375 E V V D C H L S D M L Q Q L H
Dog Lupus familis XP_547091 832 93293 R603 E A V D C H L R D M L Q Q L H
Cat Felis silvestris
Mouse Mus musculus Q07832 603 68282 S375 E A I E C H L S D L L Q Q L T
Rat Rattus norvegicus Q62673 603 68295 S375 E A I E C H L S D L L Q Q L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505317 482 55166 V262 M L Q Q L T T V N V A K P S E
Chicken Gallus gallus NP_001025810 595 66904 A366 D T I E C H L A D M L Q Q L T
Frog Xenopus laevis P70032 598 68193 S369 E P A D C Y L S E M L Q Q L T
Zebra Danio Brachydanio rerio NP_001003890 595 67743 T366 E Q P D T H L T D M L Q Q L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P52304 576 66955 I338 K A N L H D A I T A S A Q V C
Honey Bee Apis mellifera XP_396707 575 66141 Q354 L D I R K M L Q T L R E Q L S
Nematode Worm Caenorhab. elegans P34331 649 73615 S376 E P E D A Y L S Q L F H Q V A
Sea Urchin Strong. purpuratus XP_784826 587 66895 A356 Q P K E D H L A S L K V H L T
Poplar Tree Populus trichocarpa
Maize Zea mays P0C8M8 626 70215 S355 R F I N T Q G S N M F G S E K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STV4 445 50410 F225 S K I D K A E F S C P S Y F A
Baker's Yeast Sacchar. cerevisiae P32562 705 81013 Q436 E V V D I E A Q R R L N D L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 69.5 N.A. 95 94.1 N.A. 69.3 80 79.7 74.3 N.A. 50.7 51.4 49.9 59.3
Protein Similarity: 100 99.8 99.8 71 N.A. 97.6 96.8 N.A. 74.7 89.8 90.5 87.5 N.A. 69.4 69.9 66.2 76.4
P-Site Identity: 100 100 100 86.6 N.A. 66.6 66.6 N.A. 0 60 66.6 66.6 N.A. 6.6 20 33.3 20
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. 26.6 86.6 80 73.3 N.A. 20 40 53.3 46.6
Percent
Protein Identity: N.A. 31.7 N.A. 26 33.9 N.A.
Protein Similarity: N.A. 50.1 N.A. 40.4 51.6 N.A.
P-Site Identity: N.A. 13.3 N.A. 6.6 40 N.A.
P-Site Similarity: N.A. 33.3 N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 24 6 0 6 6 12 12 0 6 6 6 0 0 24 % A
% Cys: 0 0 0 0 48 0 0 0 0 6 0 0 0 0 6 % C
% Asp: 6 6 0 53 6 6 0 0 48 0 0 0 6 0 0 % D
% Glu: 59 0 6 24 0 6 6 0 6 0 0 6 0 6 6 % E
% Phe: 0 6 0 0 0 0 0 6 0 0 12 0 0 6 0 % F
% Gly: 0 0 0 0 0 0 6 0 0 0 0 6 0 0 0 % G
% His: 0 0 0 0 6 53 0 0 0 0 0 6 6 0 24 % H
% Ile: 0 0 36 0 6 0 0 6 0 0 0 0 0 0 0 % I
% Lys: 6 6 6 0 12 0 0 0 0 0 6 6 0 0 6 % K
% Leu: 6 6 0 6 6 0 71 0 0 30 59 0 0 71 0 % L
% Met: 6 0 0 0 0 6 0 0 0 48 0 0 0 0 0 % M
% Asn: 0 0 6 6 0 0 0 0 12 0 0 6 0 0 0 % N
% Pro: 0 18 6 0 0 0 0 0 0 0 6 0 6 0 0 % P
% Gln: 6 6 6 6 0 6 0 12 6 0 0 53 71 0 0 % Q
% Arg: 6 0 0 6 0 0 0 6 6 6 6 0 0 0 0 % R
% Ser: 6 0 0 0 0 0 0 48 12 0 6 6 6 6 6 % S
% Thr: 0 6 0 0 12 6 6 6 12 0 0 0 0 0 30 % T
% Val: 0 24 30 0 0 0 0 6 0 6 0 6 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 12 0 0 0 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _