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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLK1 All Species: 40.91
Human Site: S450 Identified Species: 56.25
UniProt: P53350 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53350 NP_005021.2 603 68255 S450 I L Y N D G D S L Q Y I E R D
Chimpanzee Pan troglodytes XP_001163623 603 68223 S450 I L Y N D G D S L Q Y I E R D
Rhesus Macaque Macaca mulatta XP_001092070 603 68240 S450 I L Y N D G D S L Q Y I E R D
Dog Lupus familis XP_547091 832 93293 S678 I L Y N D G D S L Q Y I E R D
Cat Felis silvestris
Mouse Mus musculus Q07832 603 68282 S450 I L Y N D G D S L Q Y I E R D
Rat Rattus norvegicus Q62673 603 68295 S450 I L Y N D G D S L Q Y I E R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505317 482 55166 Q330 Y N D G D S L Q Y I E Q D G T
Chicken Gallus gallus NP_001025810 595 66904 S441 I M Y N D G D S L Q Y I E Q N
Frog Xenopus laevis P70032 598 68193 S444 I M Y N D G D S L Q Y I E R N
Zebra Danio Brachydanio rerio NP_001003890 595 67743 S441 I M C A D G D S L Q Y I D R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P52304 576 66955 D410 G F G Y Q L C D E G I G V M F
Honey Bee Apis mellifera XP_396707 575 66141 I422 F N D G T R L I M L A N C F N
Nematode Worm Caenorhab. elegans P34331 649 73615 T455 D Q A G N E L T Y I E K S N K
Sea Urchin Strong. purpuratus XP_784826 587 66895 T431 L L H A N A D T L E Y I E R D
Poplar Tree Populus trichocarpa
Maize Zea mays P0C8M8 626 70215 V472 L S G N E V W V K K W V D Y S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STV4 445 50410 T293 F D D P E E Q T Y A Q D G T R
Baker's Yeast Sacchar. cerevisiae P32562 705 81013 E553 L R L A D A E E F W Y I S Y D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 69.5 N.A. 95 94.1 N.A. 69.3 80 79.7 74.3 N.A. 50.7 51.4 49.9 59.3
Protein Similarity: 100 99.8 99.8 71 N.A. 97.6 96.8 N.A. 74.7 89.8 90.5 87.5 N.A. 69.4 69.9 66.2 76.4
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 6.6 80 86.6 66.6 N.A. 0 0 0 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 100 100 86.6 N.A. 0 13.3 13.3 86.6
Percent
Protein Identity: N.A. 31.7 N.A. 26 33.9 N.A.
Protein Similarity: N.A. 50.1 N.A. 40.4 51.6 N.A.
P-Site Identity: N.A. 6.6 N.A. 0 26.6 N.A.
P-Site Similarity: N.A. 46.6 N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 18 0 12 0 0 0 6 6 0 0 0 0 % A
% Cys: 0 0 6 0 0 0 6 0 0 0 0 0 6 0 0 % C
% Asp: 6 6 18 0 65 0 59 6 0 0 0 6 18 0 48 % D
% Glu: 0 0 0 0 12 12 6 6 6 6 12 0 53 0 0 % E
% Phe: 12 6 0 0 0 0 0 0 6 0 0 0 0 6 6 % F
% Gly: 6 0 12 18 0 53 0 0 0 6 0 6 6 6 0 % G
% His: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 53 0 0 0 0 0 0 6 0 12 6 65 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 6 6 0 6 0 0 6 % K
% Leu: 18 42 6 0 0 6 18 0 59 6 0 0 0 0 0 % L
% Met: 0 18 0 0 0 0 0 0 6 0 0 0 0 6 0 % M
% Asn: 0 12 0 53 12 0 0 0 0 0 0 6 0 6 24 % N
% Pro: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 6 0 0 6 0 6 6 0 53 6 6 0 6 0 % Q
% Arg: 0 6 0 0 0 6 0 0 0 0 0 0 0 53 6 % R
% Ser: 0 6 0 0 0 6 0 53 0 0 0 0 12 0 6 % S
% Thr: 0 0 0 0 6 0 0 18 0 0 0 0 0 6 6 % T
% Val: 0 0 0 0 0 6 0 6 0 0 0 6 6 0 0 % V
% Trp: 0 0 0 0 0 0 6 0 0 6 6 0 0 0 0 % W
% Tyr: 6 0 48 6 0 0 0 0 18 0 65 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _