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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
36.06
Human Site:
S565
Identified Species:
49.58
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S565
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S565
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S565
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Dog
Lupus familis
XP_547091
832
93293
S793
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S565
D
F
Q
T
Y
R
L
S
L
L
E
E
Y
G
C
Rat
Rattus norvegicus
Q62673
603
68295
S565
D
F
R
T
Y
R
L
S
L
L
E
E
Y
G
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
I445
R
T
Y
K
L
S
L
I
E
E
H
G
C
C
R
Chicken
Gallus gallus
NP_001025810
595
66904
S556
D
F
R
T
Y
K
L
S
L
I
E
E
H
G
C
Frog
Xenopus laevis
P70032
598
68193
S559
E
F
R
T
Y
K
L
S
L
I
Q
E
F
G
C
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
T556
E
F
Y
T
Y
K
M
T
L
I
E
E
F
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
P525
H
M
K
L
I
L
C
P
R
M
S
A
I
T
Y
Honey Bee
Apis mellifera
XP_396707
575
66141
F537
Y
I
D
T
E
K
N
F
R
T
Y
R
F
Q
T
Nematode Worm
Caenorhab. elegans
P34331
649
73615
N570
R
M
L
T
Y
K
L
N
N
L
Q
R
N
G
C
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
N546
N
F
R
T
F
R
L
N
L
I
E
K
H
G
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
F587
K
T
K
N
A
T
L
F
R
L
S
N
K
T
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
E408
Q
N
A
A
G
D
A
E
E
Y
L
K
F
Y
K
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
V668
E
S
T
T
Y
P
L
V
E
V
L
K
Y
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
6.6
80
66.6
53.3
N.A.
0
6.6
40
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
100
93.3
N.A.
13.3
20
60
100
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
33.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
6
6
0
6
0
0
0
0
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
6
0
0
0
0
0
6
6
65
% C
% Asp:
42
0
6
0
0
6
0
0
0
0
0
0
0
0
0
% D
% Glu:
18
0
0
0
6
0
0
6
18
6
53
53
0
0
6
% E
% Phe:
0
59
0
0
6
0
0
12
0
0
0
0
24
0
0
% F
% Gly:
0
0
0
0
6
0
0
0
0
0
0
6
0
71
0
% G
% His:
6
0
0
0
0
0
0
0
0
0
6
0
12
0
0
% H
% Ile:
0
6
0
0
6
0
0
6
0
24
0
0
6
0
0
% I
% Lys:
6
0
12
6
0
30
0
0
0
0
0
18
6
0
6
% K
% Leu:
0
0
6
6
6
6
77
0
59
48
12
0
0
0
0
% L
% Met:
0
12
0
0
0
0
6
0
0
6
0
0
0
0
0
% M
% Asn:
6
6
0
6
0
0
6
12
6
0
0
6
6
0
0
% N
% Pro:
0
0
0
0
0
6
0
6
0
0
0
0
0
0
0
% P
% Gln:
6
0
6
0
0
0
0
0
0
0
12
0
0
6
0
% Q
% Arg:
12
0
48
0
0
42
0
0
18
0
0
12
0
0
6
% R
% Ser:
0
6
0
0
0
6
0
48
0
0
12
0
0
0
0
% S
% Thr:
0
12
6
77
0
6
0
6
0
6
0
0
0
12
6
% T
% Val:
0
0
0
0
0
0
0
6
0
6
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
12
0
65
0
0
0
0
6
6
0
42
6
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _