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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
31.52
Human Site:
T459
Identified Species:
43.33
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Dog
Lupus familis
XP_547091
832
93293
T687
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Rat
Rattus norvegicus
Q62673
603
68295
T459
Q
Y
I
E
R
D
G
T
E
S
Y
L
T
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
S339
I
E
Q
D
G
T
E
S
Y
L
T
V
R
S
Y
Chicken
Gallus gallus
NP_001025810
595
66904
T450
Q
Y
I
E
Q
N
N
T
E
S
Y
F
T
V
R
Frog
Xenopus laevis
P70032
598
68193
T453
Q
Y
I
E
R
N
N
T
E
S
Y
L
N
V
R
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
L450
Q
Y
I
D
R
N
S
L
E
S
Y
L
S
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
D419
G
I
G
V
M
F
N
D
T
T
K
L
I
L
L
Honey Bee
Apis mellifera
XP_396707
575
66141
H431
L
A
N
C
F
N
I
H
Y
I
N
R
E
G
N
Nematode Worm
Caenorhab. elegans
P34331
649
73615
H464
I
E
K
S
N
K
E
H
Y
F
S
M
H
S
G
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
N440
E
Y
I
E
R
D
G
N
E
K
Y
C
R
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
K481
K
W
V
D
Y
S
S
K
Y
G
M
G
Y
N
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
T302
A
Q
D
G
T
R
D
T
G
P
L
T
L
N
A
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
R562
W
Y
I
S
Y
D
D
R
E
G
W
V
A
S
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
66.6
73.3
60
N.A.
6.6
0
0
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
80
80
80
N.A.
20
13.3
6.6
66.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
0
0
0
0
0
0
0
0
0
0
6
0
6
% A
% Cys:
0
0
0
6
0
0
0
0
0
0
0
6
0
0
0
% C
% Asp:
0
0
6
18
0
48
12
6
0
0
0
0
0
0
0
% D
% Glu:
6
12
0
53
0
0
12
0
65
0
0
0
6
0
0
% E
% Phe:
0
0
0
0
6
6
0
0
0
6
0
6
0
0
0
% F
% Gly:
6
0
6
6
6
0
42
0
6
12
0
6
0
6
12
% G
% His:
0
0
0
0
0
0
0
12
0
0
0
0
6
0
6
% H
% Ile:
12
6
65
0
0
0
6
0
0
6
0
0
6
0
0
% I
% Lys:
6
0
6
0
0
6
0
6
0
6
6
0
0
0
0
% K
% Leu:
6
0
0
0
0
0
0
6
0
6
6
53
6
12
12
% L
% Met:
0
0
0
0
6
0
0
0
0
0
6
6
0
0
0
% M
% Asn:
0
0
6
0
6
24
18
6
0
0
6
0
6
12
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% P
% Gln:
53
6
6
0
6
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
53
6
0
6
0
0
0
6
12
0
18
% R
% Ser:
0
0
0
12
0
6
12
6
0
53
6
0
6
18
36
% S
% Thr:
0
0
0
0
6
6
0
53
6
6
6
6
42
0
0
% T
% Val:
0
0
6
6
0
0
0
0
0
0
0
12
0
53
0
% V
% Trp:
6
6
0
0
0
0
0
0
0
0
6
0
0
0
0
% W
% Tyr:
0
65
0
0
12
0
0
0
24
0
59
0
6
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _