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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLK1 All Species: 48.79
Human Site: Y268 Identified Species: 67.08
UniProt: P53350 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53350 NP_005021.2 603 68255 Y268 L R I K K N E Y S I P K H I N
Chimpanzee Pan troglodytes XP_001163623 603 68223 Y268 L R I K K N E Y S I P K H I N
Rhesus Macaque Macaca mulatta XP_001092070 603 68240 Y268 L R I K K N E Y S I P K H I N
Dog Lupus familis XP_547091 832 93293 Y496 L R I K K N D Y S I P K H I N
Cat Felis silvestris
Mouse Mus musculus Q07832 603 68282 Y268 L R I K K N E Y S I P K H I N
Rat Rattus norvegicus Q62673 603 68295 Y268 L R I K K N E Y S I P K H I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505317 482 55166 R165 S L I Q K M L R L D P A T R P
Chicken Gallus gallus NP_001025810 595 66904 Y258 I R I K K N E Y T I P K H I N
Frog Xenopus laevis P70032 598 68193 Y259 M R I K K N E Y S I P K H I N
Zebra Danio Brachydanio rerio NP_001003890 595 67743 Y254 I R I K K N E Y S V P R H I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P52304 576 66955 Y240 S K I K K C E Y R V P S Y L R
Honey Bee Apis mellifera XP_396707 575 66141 Y238 A R I K Q V Q Y K I P T H I N
Nematode Worm Caenorhab. elegans P34331 649 73615 Y253 S R I R H N N Y T I P S I A T
Sea Urchin Strong. purpuratus XP_784826 587 66895 Y242 Q R I K R N E Y R V P S H V S
Poplar Tree Populus trichocarpa
Maize Zea mays P0C8M8 626 70215 E251 Y K R I K A C E Y S F P D H V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STV4 445 50410 V128 D Y C H S K G V Y H R D L K P
Baker's Yeast Sacchar. cerevisiae P32562 705 81013 R296 I Y E R I K C R D F S F P R D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 69.5 N.A. 95 94.1 N.A. 69.3 80 79.7 74.3 N.A. 50.7 51.4 49.9 59.3
Protein Similarity: 100 99.8 99.8 71 N.A. 97.6 96.8 N.A. 74.7 89.8 90.5 87.5 N.A. 69.4 69.9 66.2 76.4
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. 20 86.6 93.3 80 N.A. 40 60 40 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 100 100 100 N.A. 66.6 73.3 53.3 80
Percent
Protein Identity: N.A. 31.7 N.A. 26 33.9 N.A.
Protein Similarity: N.A. 50.1 N.A. 40.4 51.6 N.A.
P-Site Identity: N.A. 6.6 N.A. 0 0 N.A.
P-Site Similarity: N.A. 13.3 N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 0 0 0 6 0 0 0 0 0 6 0 6 0 % A
% Cys: 0 0 6 0 0 6 12 0 0 0 0 0 0 0 0 % C
% Asp: 6 0 0 0 0 0 6 0 6 6 0 6 6 0 6 % D
% Glu: 0 0 6 0 0 0 59 6 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 6 6 6 0 0 0 % F
% Gly: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 6 6 0 0 0 0 6 0 0 65 6 0 % H
% Ile: 18 0 83 6 6 0 0 0 0 59 0 0 6 59 0 % I
% Lys: 0 12 0 71 71 12 0 0 6 0 0 48 0 6 0 % K
% Leu: 36 6 0 0 0 0 6 0 6 0 0 0 6 6 0 % L
% Met: 6 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 65 6 0 0 0 0 0 0 0 59 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 83 6 6 0 12 % P
% Gln: 6 0 0 6 6 0 6 0 0 0 0 0 0 0 0 % Q
% Arg: 0 71 6 12 6 0 0 12 12 0 6 6 0 12 6 % R
% Ser: 18 0 0 0 6 0 0 0 48 6 6 18 0 0 6 % S
% Thr: 0 0 0 0 0 0 0 0 12 0 0 6 6 0 6 % T
% Val: 0 0 0 0 0 6 0 6 0 18 0 0 0 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 12 0 0 0 0 0 77 12 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _