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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACLY
All Species:
31.52
Human Site:
Y682
Identified Species:
63.03
UniProt:
P53396
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53396
NP_001087.2
1101
120839
Y682
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Chimpanzee
Pan troglodytes
XP_511495
1775
198342
Y843
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Rhesus Macaque
Macaca mulatta
XP_001108114
1137
124370
H718
G
R
L
S
A
G
V
H
Q
G
L
L
S
A
G
Dog
Lupus familis
XP_850198
1101
120705
Y682
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q91V92
1091
119709
Y672
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Rat
Rattus norvegicus
P16638
1100
120617
Y681
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001025711
1101
121113
Y682
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Frog
Xenopus laevis
NP_001088452
1101
120767
F682
S
R
T
T
D
G
V
F
E
G
V
A
I
G
G
Zebra Danio
Brachydanio rerio
NP_001002649
1092
119691
Y673
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523755
1112
121387
I694
S
K
A
T
D
G
V
I
E
G
I
A
I
G
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P53585
1106
121598
Y682
S
Q
N
T
N
G
V
Y
E
G
I
A
I
G
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X097
670
72608
K294
V
K
Q
G
I
I
T
K
P
I
V
A
W
A
I
Conservation
Percent
Protein Identity:
100
59.9
90.3
98.1
N.A.
97.1
97.5
N.A.
N.A.
93.1
89.3
86.3
N.A.
69.3
N.A.
60.8
N.A.
Protein Similarity:
100
61.1
92.3
99.4
N.A.
98.3
98.6
N.A.
N.A.
96.5
95.3
93
N.A.
81.5
N.A.
76.5
N.A.
P-Site Identity:
100
100
33.3
100
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
73.3
N.A.
73.3
N.A.
P-Site Similarity:
100
100
60
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
86.6
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
39.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
49.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
9
0
0
0
0
0
0
92
0
17
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
75
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
84
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
9
0
92
0
0
0
92
0
0
0
84
92
% G
% His:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
9
0
9
0
9
17
0
84
0
9
% I
% Lys:
0
17
0
0
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
0
0
0
9
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
9
0
0
0
0
0
0
% Q
% Arg:
0
75
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
84
0
0
9
0
0
0
0
0
0
0
0
9
0
0
% S
% Thr:
0
0
67
84
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
0
92
0
0
0
75
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _