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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP1
All Species:
30.3
Human Site:
S126
Identified Species:
51.28
UniProt:
P53582
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53582
NP_055958.2
386
43215
S126
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Chimpanzee
Pan troglodytes
XP_001165908
367
40994
S126
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Rhesus Macaque
Macaca mulatta
XP_001099172
464
51572
S204
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Dog
Lupus familis
XP_544993
353
39779
M123
V
L
D
I
A
A
G
M
I
K
P
G
V
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BP48
386
43203
S126
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Rat
Rattus norvegicus
NP_001099946
386
43187
S126
E
Q
A
L
K
G
T
S
Q
I
K
L
L
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIM5
385
43103
S126
E
Q
A
L
K
G
T
S
Q
I
K
I
L
S
P
Frog
Xenopus laevis
Q7ZWV9
385
43178
S126
E
Q
T
L
K
G
T
S
Q
I
K
T
L
S
P
Zebra Danio
Brachydanio rerio
Q4QRK0
386
43548
S125
E
Q
T
M
K
G
T
S
Q
I
K
I
L
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651281
374
41708
E124
V
L
D
D
E
E
I
E
G
M
R
V
A
G
R
Honey Bee
Apis mellifera
XP_393865
377
42283
G128
L
D
D
E
E
I
E
G
M
R
V
A
C
K
L
Nematode Worm
Caenorhab. elegans
NP_500396
371
41724
A123
E
K
E
G
L
K
V
A
C
K
L
G
R
E
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SLN5
398
43974
V139
N
S
D
L
Q
H
V
V
E
I
K
T
P
E
Q
Baker's Yeast
Sacchar. cerevisiae
Q01662
387
43355
I127
R
N
D
R
L
N
N
I
P
I
Y
K
K
D
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.8
82.7
90.1
N.A.
98.1
97.9
N.A.
N.A.
94.8
88
86.7
N.A.
61.6
66.3
60.3
N.A.
Protein Similarity:
100
95
83.1
91.1
N.A.
99.4
99.4
N.A.
N.A.
97.9
95
93.7
N.A.
75.1
79.5
72
N.A.
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
N.A.
86.6
80
66.6
N.A.
0
0
6.6
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
N.A.
93.3
80
93.3
N.A.
26.6
6.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.7
47.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
69.1
62.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
43
0
8
8
0
8
0
0
0
8
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
8
% C
% Asp:
0
8
36
8
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
65
0
8
8
15
8
8
8
8
0
0
0
0
15
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
58
8
8
8
0
0
15
0
8
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
8
8
8
72
0
15
0
0
0
% I
% Lys:
0
8
0
0
58
8
0
0
0
15
65
8
8
8
0
% K
% Leu:
8
15
0
58
15
0
0
0
0
0
8
36
58
0
8
% L
% Met:
0
0
0
8
0
0
0
8
8
8
0
0
0
0
0
% M
% Asn:
8
8
0
0
0
8
8
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
8
0
8
0
15
% P
% Gln:
0
58
0
0
8
0
0
0
58
0
0
0
0
0
15
% Q
% Arg:
8
0
0
8
0
0
0
0
0
8
8
0
8
0
8
% R
% Ser:
0
8
0
0
0
0
0
58
0
0
0
0
0
50
36
% S
% Thr:
0
0
15
0
0
0
58
0
0
0
0
15
0
8
8
% T
% Val:
15
0
0
0
0
0
15
8
0
0
8
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _