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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP1
All Species:
35.15
Human Site:
Y228
Identified Species:
59.49
UniProt:
P53582
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53582
NP_055958.2
386
43215
Y228
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Chimpanzee
Pan troglodytes
XP_001165908
367
40994
Y209
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Rhesus Macaque
Macaca mulatta
XP_001099172
464
51572
Y306
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Dog
Lupus familis
XP_544993
353
39779
D198
Y
R
N
G
Y
H
G
D
L
N
E
T
F
F
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BP48
386
43203
Y228
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Rat
Rattus norvegicus
NP_001099946
386
43187
Y228
I
T
L
Y
R
N
G
Y
H
G
D
L
N
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIM5
385
43103
Y228
I
T
V
Y
R
N
G
Y
H
G
D
L
N
E
T
Frog
Xenopus laevis
Q7ZWV9
385
43178
Y228
I
T
V
Y
R
D
G
Y
H
G
D
L
N
E
T
Zebra Danio
Brachydanio rerio
Q4QRK0
386
43548
Y227
I
T
V
Y
H
N
G
Y
H
G
D
L
N
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651281
374
41708
F215
V
T
V
Y
H
R
G
F
H
G
D
L
N
E
T
Honey Bee
Apis mellifera
XP_393865
377
42283
F218
V
T
V
Y
H
N
G
F
H
G
D
L
N
E
T
Nematode Worm
Caenorhab. elegans
NP_500396
371
41724
F209
V
T
V
Y
H
R
G
F
H
G
D
L
N
E
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SLN5
398
43974
C239
V
T
V
C
Y
K
G
C
H
G
D
L
N
E
T
Baker's Yeast
Sacchar. cerevisiae
Q01662
387
43355
Y227
V
S
L
Y
Y
Q
G
Y
H
A
D
L
N
E
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.8
82.7
90.1
N.A.
98.1
97.9
N.A.
N.A.
94.8
88
86.7
N.A.
61.6
66.3
60.3
N.A.
Protein Similarity:
100
95
83.1
91.1
N.A.
99.4
99.4
N.A.
N.A.
97.9
95
93.7
N.A.
75.1
79.5
72
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
N.A.
93.3
86.6
86.6
N.A.
66.6
73.3
66.6
N.A.
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
86.6
93.3
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.7
47.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
69.1
62.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
8
0
0
93
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
8
0
0
93
0
% E
% Phe:
0
0
0
0
0
0
0
22
0
0
0
0
8
8
0
% F
% Gly:
0
0
0
8
0
0
100
0
0
86
0
0
0
0
0
% G
% His:
0
0
0
0
29
8
0
0
93
0
0
0
0
0
0
% H
% Ile:
58
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
43
0
0
0
0
0
8
0
0
93
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
58
0
0
0
8
0
0
93
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
50
15
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
86
0
0
0
0
0
0
0
0
0
8
0
0
93
% T
% Val:
36
0
50
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
86
22
0
0
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _