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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METAP1 All Species: 35.76
Human Site: Y253 Identified Species: 60.51
UniProt: P53582 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53582 NP_055958.2 386 43215 Y253 R K L V Q T T Y E C L M Q A I
Chimpanzee Pan troglodytes XP_001165908 367 40994 Y234 R K L V Q T T Y E C L M Q A I
Rhesus Macaque Macaca mulatta XP_001099172 464 51572 Y331 R K L V Q T T Y E C L M Q A I
Dog Lupus familis XP_544993 353 39779 L223 V Q T T Y E C L M Q A I D A V
Cat Felis silvestris
Mouse Mus musculus Q8BP48 386 43203 Y253 R K L V Q T T Y E C L M Q A I
Rat Rattus norvegicus NP_001099946 386 43187 Y253 R K L V Q T T Y E C L M Q A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZIM5 385 43103 Y253 K R L V Q T T Y E C L M Q A I
Frog Xenopus laevis Q7ZWV9 385 43178 Y253 K R L V E T T Y E C L M Q A I
Zebra Danio Brachydanio rerio Q4QRK0 386 43548 Y252 K R L V Q T T Y E C L M Q A I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651281 374 41708 H240 K K L V Q V T H E A L S K A I
Honey Bee Apis mellifera XP_393865 377 42283 H243 K K L V E V T H E C L S K A I
Nematode Worm Caenorhab. elegans NP_500396 371 41724 F235 R K L V K V T F E C L Q Q A I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SLN5 398 43974 Y264 R Q L V K C T Y E C L E K A I
Baker's Yeast Sacchar. cerevisiae Q01662 387 43355 R253 L N T T E T S R E C L K L A I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.8 82.7 90.1 N.A. 98.1 97.9 N.A. N.A. 94.8 88 86.7 N.A. 61.6 66.3 60.3 N.A.
Protein Similarity: 100 95 83.1 91.1 N.A. 99.4 99.4 N.A. N.A. 97.9 95 93.7 N.A. 75.1 79.5 72 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 93.3 N.A. N.A. 86.6 80 86.6 N.A. 60 60 73.3 N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 80 86.6 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 55.7 47.5 N.A.
Protein Similarity: N.A. N.A. N.A. 69.1 62.7 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 8 8 0 0 100 0 % A
% Cys: 0 0 0 0 0 8 8 0 0 86 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % D
% Glu: 0 0 0 0 22 8 0 0 93 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 86 % I
% Lys: 36 58 0 0 15 0 0 0 0 0 0 8 22 0 0 % K
% Leu: 8 0 86 0 0 0 0 8 0 0 93 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 58 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 15 0 0 58 0 0 0 0 8 0 8 65 0 0 % Q
% Arg: 50 22 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 8 0 0 0 0 15 0 0 0 % S
% Thr: 0 0 15 15 0 65 86 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 86 0 22 0 0 0 0 0 0 0 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 65 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _