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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPA All Species: 23.33
Human Site: S978 Identified Species: 39.49
UniProt: P53621 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53621 NP_001091868.1 1224 138346 S978 Q A L P C L P S M Y G Y P N R
Chimpanzee Pan troglodytes XP_001171498 1224 138329 S978 Q A L P C L P S M Y G Y P N R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536131 1241 139883 S995 Q A L P C L P S M Y G Y P H R
Cat Felis silvestris
Mouse Mus musculus Q8CIE6 1224 138428 S978 Q A L P C L P S M Y S Y P N R
Rat Rattus norvegicus O35142 905 102533 S684 A I S K C Q F S L A Q E C L H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026576 1224 138533 T978 Q A L P C L P T M Y G Y P H R
Frog Xenopus laevis NP_001086488 1224 138559 A978 Q A L P G L P A M Y G Y P Q R
Zebra Danio Brachydanio rerio NP_001001941 1226 138438 C980 L G L P S L P C L H S F P L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O62621 914 102694 K694 L V K E C M Q K A N D L S G L
Honey Bee Apis mellifera XP_623198 1214 137977 S968 A S L P N I P S L Y G Y P Q R
Nematode Worm Caenorhab. elegans Q20168 1000 111088 S780 K A K A S G H S E K S S R K I
Sea Urchin Strong. purpuratus XP_001179078 1211 136717 P965 V G L P S L P P L C G Y A H R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94A40 1216 136548 V972 R A F S S C P V V P L A I E R
Baker's Yeast Sacchar. cerevisiae P53622 1201 135589 P962 P S T P C E L P A Q L G Y V R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 N.A. 96.8 N.A. 98.5 23.1 N.A. N.A. 96.5 93.1 86.3 N.A. 20.1 73.3 20.7 77.5
Protein Similarity: 100 99.9 N.A. 97.7 N.A. 99.1 37.8 N.A. N.A. 98.5 97.1 94.7 N.A. 37.9 85 39 87
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 13.3 N.A. N.A. 86.6 80 40 N.A. 6.6 60 13.3 46.6
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 20 N.A. N.A. 100 86.6 60 N.A. 13.3 80 20 60
Percent
Protein Identity: N.A. N.A. N.A. 55.5 43.8 N.A.
Protein Similarity: N.A. N.A. N.A. 72.4 64.1 N.A.
P-Site Identity: N.A. N.A. N.A. 20 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 58 0 8 0 0 0 8 15 8 0 8 8 0 0 % A
% Cys: 0 0 0 0 58 8 0 8 0 8 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % D
% Glu: 0 0 0 8 0 8 0 0 8 0 0 8 0 8 0 % E
% Phe: 0 0 8 0 0 0 8 0 0 0 0 8 0 0 0 % F
% Gly: 0 15 0 0 8 8 0 0 0 0 50 8 0 8 0 % G
% His: 0 0 0 0 0 0 8 0 0 8 0 0 0 22 8 % H
% Ile: 0 8 0 0 0 8 0 0 0 0 0 0 8 0 8 % I
% Lys: 8 0 15 8 0 0 0 8 0 8 0 0 0 8 0 % K
% Leu: 15 0 65 0 0 58 8 0 29 0 15 8 0 15 8 % L
% Met: 0 0 0 0 0 8 0 0 43 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 8 0 0 0 22 0 % N
% Pro: 8 0 0 72 0 0 72 15 0 8 0 0 58 0 0 % P
% Gln: 43 0 0 0 0 8 8 0 0 8 8 0 0 15 0 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 79 % R
% Ser: 0 15 8 8 29 0 0 50 0 0 22 8 8 0 0 % S
% Thr: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 8 8 0 0 0 0 0 8 8 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 50 0 58 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _