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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
15.15
Human Site:
S146
Identified Species:
25.64
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
S146
G
K
K
V
G
T
A
S
E
N
V
Y
V
N
T
Chimpanzee
Pan troglodytes
XP_508684
463
51907
S146
G
K
K
V
G
T
A
S
E
N
V
Y
V
N
T
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
S146
G
K
K
V
G
T
A
S
E
N
V
Y
V
N
T
Dog
Lupus familis
XP_535784
481
54085
S167
G
T
K
M
G
T
T
S
E
K
A
K
V
N
T
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
I146
G
K
K
V
E
S
H
I
E
K
V
N
M
N
A
Rat
Rattus norvegicus
P80067
462
52217
S146
G
K
K
M
A
N
H
S
E
K
V
Y
V
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
L152
K
I
S
S
A
S
P
L
G
G
V
Y
V
N
Q
Chicken
Gallus gallus
P43233
340
37569
I34
S
S
D
L
V
N
H
I
N
K
L
N
T
T
G
Frog
Xenopus laevis
NP_001080511
458
51565
R147
V
S
A
E
S
G
V
R
V
N
P
D
P
F
P
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
H147
P
P
R
V
D
R
R
H
M
L
G
F
E
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
D73
S
S
V
Y
G
E
N
D
K
A
K
W
G
L
M
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
V149
K
V
H
T
N
A
K
V
K
R
L
K
S
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
R54
F
A
A
L
G
R
T
R
D
A
L
R
F
A
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
Q52
S
V
S
Q
I
L
G
Q
S
R
H
V
L
S
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
60
N.A.
46.6
60
N.A.
26.6
0
6.6
6.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
66.6
N.A.
60
66.6
N.A.
33.3
13.3
6.6
26.6
N.A.
N.A.
N.A.
20
13.3
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
15
0
15
8
22
0
0
15
8
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
0
0
8
8
0
0
8
0
0
0
% D
% Glu:
0
0
0
8
8
8
0
0
43
0
0
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
8
15
8
% F
% Gly:
43
0
0
0
43
8
8
0
8
8
8
0
8
0
8
% G
% His:
0
0
8
0
0
0
22
8
0
0
8
0
0
8
0
% H
% Ile:
0
8
0
0
8
0
0
15
0
0
0
0
0
0
0
% I
% Lys:
15
36
43
0
0
0
8
0
15
29
8
15
0
0
8
% K
% Leu:
0
0
0
15
0
8
0
8
0
8
22
0
8
8
0
% L
% Met:
0
0
0
15
0
0
0
0
8
0
0
0
8
0
8
% M
% Asn:
0
0
0
0
8
15
8
0
8
29
0
15
0
50
0
% N
% Pro:
8
8
0
0
0
0
8
0
0
0
8
0
8
0
8
% P
% Gln:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
0
0
15
8
15
0
15
0
8
0
0
15
% R
% Ser:
22
22
15
8
8
15
0
36
8
0
0
0
8
8
0
% S
% Thr:
0
8
0
8
0
29
15
0
0
0
0
0
8
8
29
% T
% Val:
8
15
8
36
8
0
8
8
8
0
43
8
43
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
36
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _