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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
15.45
Human Site:
S278
Identified Species:
26.15
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
S278
I
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Chimpanzee
Pan troglodytes
XP_508684
463
51907
S278
I
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
S278
I
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Dog
Lupus familis
XP_535784
481
54085
T299
I
L
T
N
N
T
Q
T
P
I
L
S
P
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
Q278
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Q
Rat
Rattus norvegicus
P80067
462
52217
Q278
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
S284
I
R
I
L
T
N
N
S
Q
T
P
I
L
S
T
Chicken
Gallus gallus
P43233
340
37569
G166
W
R
Y
W
T
E
R
G
L
V
S
G
G
L
Y
Frog
Xenopus laevis
NP_001080511
458
51565
S279
L
S
Q
K
P
I
L
S
P
Q
Q
V
V
S
C
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
Q279
Q
Q
P
V
F
S
P
Q
Q
V
V
S
C
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
P205
T
A
N
N
G
C
K
P
Y
P
F
P
P
C
E
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
V281
L
V
F
S
T
Q
D
V
V
S
C
S
E
Y
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
K186
A
Y
T
Q
A
T
G
K
P
I
S
L
S
E
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
K184
A
Y
H
Q
A
F
G
K
G
I
S
L
S
E
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
6.6
N.A.
6.6
6.6
N.A.
93.3
13.3
13.3
13.3
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
100
13.3
N.A.
26.6
26.6
N.A.
93.3
13.3
33.3
33.3
N.A.
N.A.
N.A.
0
26.6
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
0
15
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
8
0
8
8
8
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
0
8
15
15
% E
% Phe:
0
0
8
0
8
8
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
15
8
8
0
0
8
8
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
36
15
29
0
0
8
0
0
0
22
15
29
0
0
0
% I
% Lys:
0
0
0
8
0
0
8
15
0
0
0
0
0
0
0
% K
% Leu:
15
8
15
29
0
0
8
0
8
0
8
29
29
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
15
22
43
29
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
8
0
8
8
22
22
29
8
15
15
22
% P
% Gln:
8
8
8
15
0
8
8
22
36
8
8
0
0
8
36
% Q
% Arg:
15
36
0
0
0
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
8
0
8
15
36
0
8
22
22
29
43
8
% S
% Thr:
8
0
15
15
43
15
0
8
15
29
0
0
0
0
8
% T
% Val:
0
8
0
8
0
0
0
8
8
15
8
8
8
0
0
% V
% Trp:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
15
8
0
0
0
0
0
8
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _